Toll-Like Receptors

Toll-like receptors (TLRs) are a class of pattern recognition receptor proteins and recognize molecules that are broadly shared by pathogens but distinguishable from host molecules. TLRs are membrane-spanning, non-catalytic and usually expressed in sentinel cells such as macrophages and dendritic cells. TLRs participate in the first line of defense against invading pathogens and play a significant role in inflammation, immune cell regulation, survival, and proliferation.

tlr pathway

Explore Your Pathways With Novus Explorer! This free bioinformatics tool is designed to facilitate scientific exploration of related genes, diseases and pathways based on co-citations.

Webinar: View our webinar on TLR Signaling Pathways in Immunity and Beyond on YouTube and download the slides from the TLR webinar

Novus Biologicals offers a variety of top quality antibodies and proteins for TLR research. Some of our most popular autophagy research products are included below. Please follow the protein name links for more details.

Plasma Membrane TLRs


Endosomal TLRs


TLR Adaptor & Accessory Proteins


TLR Downstream Signaling Proteins