XPF Antibody (XPF 3F2/3) [FITC]

Product Discontinued

XPF Antibody (XPF 3F2/3) [FITC] Summary

• Immunogen: A recombinant His-tagged fragment of human XPF protein produced in E. coli
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ERCC4
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for XPF Antibody (XPF 3F2/3) [FITC]

• DNA excision repair protein ERCC-4
• DNA repair protein complementing XP-F cells
• EC 3.1
• ERCC11
• ERCC4
• excision repair cross-complementing rodent repair deficiency, complementationgroup 4
• xeroderma pigmentosum, complementation group F
• XPF
• XPFcomplementing defective, in Chinese hamster

Background

XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ERCC4