XBP1 Antibody [DyLight 650]

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Product Details

Summary
Product Discontinued
View other related XBP1 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-77681C
    • Availability
      Product Discontinued

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XBP1 Antibody [DyLight 650] Summary

Immunogen
A genomic peptide made to an internal region of the human XBP1 protein (within residues 100-250). [Swiss-Prot P17861]
Localization
Nucleus
Specificity
This antibody is specific for both XBP1s and XBP1u.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
XBP1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This XBP1 antibody is useful for ICC/IF and Immunohistochemistry-paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for XBP1 Antibody [DyLight 650]

  • HTF
  • TREB5
  • X-box binding protein 1
  • X-box-binding protein 1
  • XBP1
  • XBP-1
  • XBP2
  • XBP2Tax-responsive element-binding protein 5

Background

X-box binding protein 1 (XBP1) is a transcription factor important in endoplasmic reticulum function and stress response. In inflammatory bowel disease, the malfunction of XBP1 is one of many contributing factors that affects the unfolded protein response and inflammation. In response to heat shock, XBP1 is erroneously spliced and several downstream proteins are resultantly mis-folded. While the effects of XBP1 issues are mainly evidenced in mucosal tissues as a response to mechanical or disease induced stress, it is also important in some brain development and cognitive ability formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional XBP1 Products

Bioinformatics Tool for XBP1 Antibody (NBP1-77681C)

Discover related pathways, diseases and genes to XBP1 Antibody (NBP1-77681C). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for XBP1 Antibody (NBP1-77681C)

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Pathways for XBP1 Antibody (NBP1-77681C)

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PTMs for XBP1 Antibody (NBP1-77681C)

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Research Areas for XBP1 Antibody (NBP1-77681C)

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Blogs on XBP1.

Analysis of Total & pSer724 IRE1 alpha, the Sensor of ER Stress
Inositol-requiring protein 1/IRE1 alpha (also called Endoplasmic Reticulum to Nucleus Signaling 1/ERN1; predicted mol wt 110 kDa) is a serine-threonine protein kinase/endoribonuclease which plays a highly critical role in unfolded protein response/U...  Read full blog post.

IRE1 - an important sensor in the unfolded protein response pathway
During cellular stress the protein folding capacity of the ER is diminished. In order to maintain homeostasis and ensure proper protein folding cells activate the unfolded protein response (UPR), a signaling network consisting of sensors and effect...  Read full blog post.

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Bioinformatics

Gene Symbol XBP1
Entrez