XAF1 Antibody Summary
Amino acids 201-218 (NQTSTMEKDVRPKTRSIN) and 301-317 (QLDLEKERYYKFKRFHF) of human XAF1, GenBank no. CAA68030.1, were used as immunogen.
In human liver, a 34 kDa band should be observed.
Protein G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.05% BSA
0.05% Sodium Azide
Protein G purified
Publications using NB100-56355 in the following applications:
Cross reacts with Human and Mouse.
Alternate Names for XAF1 Antibody
BIRC4-binding protein BIRC4BPBIRC4 binding protein HSXIAPAF1 XIAP associated factor 1 XIAPAF1XIAP-associated factor 1 Background
The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
for 1 year from date of receipt.
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Publications for XAF1 Antibody (NB100-56355)(5)
We have publications tested in 2 confirmed species: Human, Mouse.
We have publications tested in 3 applications: IHC, IHC-P, WB.
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Publications using NB100-56355
Lunardi A, Ala U, Epping MT et al. A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nat Genet. 2013 Jul [PMID:23727860]
Kempkensteffen Carsten, Fritzsche Florian Rudolf, Johannsen Manfred et al. Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer. BMC Cancer. 2009 [PMID:19664236] (IHC, Human) IHC
Straszewski-Chavez SL, Visintin IP, Karassina N et al. XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway. J Biol Chem. 2007 Apr 27 [PMID:17329253]
Xia Y, Novak R, Lewis J et al. Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP. Mol Cell Biochem. 2006 Jun [PMID:16432762] (WB) WB
Wang X, Zhu C, Wang X et al. X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia. Neurobiol Dis. 2004 Jun [PMID:15207275] (IHC-P, Mouse) IHC-P
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