VPS4B Antibody

Western Blot: VPS4B Antibody [H00009525-A01] - Analysis of VPS4B expression in Y-79 (Cat # L042V1).

Product Discontinued

VPS4B Antibody Summary

• Immunogen: VPS4B (AAH39574, 1 a.a. - 444 a.a.) full-length recombinant protein with GST tag. MSSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSNTKPTVNEHDLLKLKKFTEDFGQEG
• Specificity: VPS4B - vacuolar protein sorting 4B (yeast)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: VPS4B
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50 % glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for VPS4B Antibody

• Cell migration-inducing gene 1 protein
• Protein SKD1
• SKD1B
• SKD1cell migration-inducing 1
• Suppressor of K(+) transport growth defect 1
• suppressor of K+ transport defect 1
• vacuolar protein sorting 4 homolog B (S. cerevisiae)
• vacuolar protein sorting 4B (yeast)
• vacuolar protein sorting 4B
• vacuolar protein sorting-associated protein 4B
• VPS42
• VPS4-2

Background

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for VPS4B Antibody (H00009525-A01)(2)

Publications using H00009525-A01

• Lin HH, Li X, Chen JL et al. Identification of an AAA ATPase VPS4B-Dependent Pathway That Modulates Epidermal Growth Factor Receptor Abundance and Signaling during Hypoxia. Mol Cell Biol. 2012-01-17 [PMID: 22252323]
• Ariumi Y, Kuroki M, Maki M et al. The ESCRT System Is Required for Hepatitis C Virus Production. PLoS One. 2011-01-11 [PMID: 21264300]

Bioinformatics

• Gene Symbol: VPS4B
• Entrez:
  • 9525(Human)
• Uniprot:
  • AAH39574(Human)