VPS4B Products

Description

VPS4B is encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq]

Bioinformatics

Entrez	9525 Human
Uniprot	AAH39574 Human NM_004869 Human NP_004860.2 Human O75351 Human
Product By Gene ID	9525
Alternate Names	Cell migration-inducing gene 1 protein Protein SKD1 SKD1B SKD1cell migration-inducing 1 Suppressor of K(+) transport growth defect 1 suppressor of K+ transport defect 1 vacuolar protein sorting 4 homolog B (S. cerevisiae) vacuolar protein sorting 4B (yeast) vacuolar protein sorting 4B vacuolar protein sorting-associated protein 4B VPS42 VPS4-2

Research Areas for VPS4B

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Autophagy