VEGFR1/Flt-1 Antibody (MM0001-7G96)

Product Discontinued

VEGFR1/Flt-1 Antibody (MM0001-7G96) Summary

• Immunogen: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human VEGFR1 N-terminal recombinant protein.
• Marker: Endothelial Cell Marker
• Specificity: VEGFR1 (MM0001-7G96). In western blot it shows no cross-reactivity with hVEGFR2, rhVEGF R3.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: FLT1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:25-200
  • Immunohistochemistry-Paraffin 1:25-200
  • Western Blot 1:1000-1:2000
• Application Notes: Western Blot and Immunohistochemistry Paraffin and Frozen WB does not show cross reactivity with hVEGFR2, rhVEGF R3.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: A 0.2 um filtered solution in PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.

Alternate Names for VEGFR1/Flt-1 Antibody (MM0001-7G96)

• EC 2.7.10
• EC 2.7.10.1
• FLT
• FLT1
• Flt-1
• Fms-like tyrosine kinase 1
• fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor)
• FRT
• Tyrosine-protein kinase FRT
• Tyrosine-protein kinase receptor FLT
• vascular endothelial growth factor receptor 1
• Vascular permeability factor receptor
• VEGF R1
• VEGFR1
• VEGFR-1

Background

VEGF Receptor 1 (also known as FLT) belongs to the src gene family and shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The protein acts as a receptor for VEGF, VEGFB and PGF. An alternatively spliced form of the gene produces a soluble protein (sFlt1) which binds vascular endothelial growth factor (VEGF) with high affinity. Because sFlt1 has a higher affinity for VEGF it may function as an inhibitor of VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells and peripheral blood monocytes. VEGFR 1 is a cell membrane receptor kinase. It has a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FLT1
• Entrez:
  • 2321(Human)
• Uniprot:
  • P17948()