VEGFR1/Flt-1 Antibody (49560) [Unconjugated] Summary
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human VEGFR1/Flt-1 Ser27-His687 Accession # NP_001153392
Detects human VEGFR1/Flt-1 in direct ELISAs and Western blots. In Western blots, this antibody does not cross-react with recombinant mouse VEGFR1, recombinant human (rh) VEGFR2, rhVEGFR3, or rhVEGFR4.
Protein A or G purified from hybridoma culture supernatant
Test in a species/application not listed above to receive a full credit towards a future purchase.
CyTOF-ready Flow Cytometry 2.5 ug/10^6 cells Western Blot 1 ug/mL
Packaging, Storage & Formulations
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.5 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for VEGFR1/Flt-1 Antibody (49560) [Unconjugated]
EC 2.7.10 EC 220.127.116.11 FLT FLT1 Flt-1 Fms-like tyrosine kinase 1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor) FRT Tyrosine-protein kinase FRT Tyrosine-protein kinase receptor FLT vascular endothelial growth factor receptor 1 Vascular permeability factor receptor VEGF R1 VEGFR1 VEGFR-1 Background
Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) is a receptor tyrosine kinase that is expressed primarily on endothelial cells and plays a role in vasculogenesis and angiogenesis. A soluble variant of VEGFR1 was also reported to bind VEGF and PlGF with high affinity and function as a potent VEGF antagonist.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
for 1 year from date of receipt.
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Publications for VEGFR1/Flt-1 Antibody (MAB321)(11)
We have publications tested in 1 confirmed species: Human.
We have publications tested in 5 applications: Cell Culture, ELISA Development, Flow Cytometry, Neutralization, Western Blot.
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Show All 11 Publications.
Publications using MAB321
A Schulz, CC Drost, B Hesse, K Beul, M Brand, GS Di Marco The Soluble Fms-like Tyrosine Kinase-1 Contributes to Structural and Functional Changes in Endothelial Cells in Chronic Kidney Disease International Journal of Molecular Sciences, 2022;23(24):. 2022 [PMID: 36555698] (Cell Culture, Human) Cell Culture
Gabriela Odent Grig Synergic effects of VEGF-A and SDF-1 on the angiogenic properties of endothelial progenitor cells J Tissue Eng Regen Med, 2016;0(0):. 2016 [PMID: 27943613] (Flow Cytometry, Human) Flow Cytometry
Jarajapu Y, Hazra S, Segal M, Li Calzi S, Jadhao C, Qian K, Mitter S, Raizada M, Boulton M, Grant M Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms. PLoS ONE, 2014;9(4):e93965. 2014 [PMID: 24713821] (Flow Cytometry, Human) Flow Cytometry
Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature, 2011;475(7355):226-30. 2011 [PMID: 21753853] (Neutralization, Human) Neutralization
Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model. Angiogenesis, 2010;13(4):337-47. 2010 [PMID: 20953695] (ELISA Development, Human) ELISA Development
Meissner M, Reichenbach G, Stein M, Hrgovic I, Kaufmann R, Gille J Down-regulation of vascular endothelial growth factor receptor 2 is a major molecular determinant of proteasome inhibitor-mediated antiangiogenic action in endothelial cells. Cancer Res., 2009;69(5):1976-84. 2009 [PMID: 19223539] (Western Blot, Human) Western Blot
Riccioni R, Senese M, Diverio D, Riti V, Mariani G, Boe A, LoCoco F, Foa R, Peschle C, Sporn M, Testa U Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels. Leuk. Res., 2008;32(8):1244-58. 2008 [PMID: 18304628] (Flow Cytometry, Human) Flow Cytometry
Lin YL, Liang YC, Chiang BL Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J. Leukoc. Biol., 2007;82(6):1473-80. 2007 [PMID: 17761954] (Neutralization, Human) Neutralization
Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells, 2007;25(8):1862-71. 2007 [PMID: 17446561] (Flow Cytometry, Human) Flow Cytometry
Caldas H, Fangusaro JR, Boue DR, Holloway MP, Altura RA Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis. Blood, 2007;109(4):1479-89. 2007 [PMID: 17038538] (Neutralization, Human) Neutralization
Caine GJ, Blann AD, Stonelake PS, Ryan P, Lip GY Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1. Eur. J. Clin. Invest., 2003;33(10):883-90. 2003 [PMID: 14511360] (ELISA Development, Human) ELISA Development
Show All 11 Publications.
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