Vav-1 Antibody (557)

Images

 
Western Blot: Vav-1 Antibody (557) [NBP2-43553] - Analysis of A. 30 ug Jurkat whole cell lysate/extract B. 30 ug NCI-H929 whole cell lysate/extract 7.5 % SDS-PAGE VAV1 antibody [557] dilution: 1:1000.
Immunocytochemistry/ Immunofluorescence: Vav-1 Antibody (557) [NBP2-43553] - VAV1 antibody [GT557] detects VAV1 protein at cell membrane and cytoplasm by immunofluorescent analysis. Sample: Jurkat cells were fixed in 4% ...read more
Immunohistochemistry-Paraffin: Vav-1 Antibody (557) [NBP2-43553] - VAV1 antibody [GT557] detects VAV1 protein by immunohistochemical analysis. Sample: Paraffin-embedded mouse spleen. VAV1 stained by VAV1 antibody ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, BvSpecies Glossary
Applications WB, ICC/IF, IHC-P
Clone
557
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Vav-1 Antibody (557) Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.
Predicted Species
Rat (92%), Porcine (96%), Bovine (96%). Backed by our 100% Guarantee.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
VAV1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Purity
Protein G purified

Alternate Names for Vav-1 Antibody (557)

  • oncogene vav
  • proto-oncogene vav
  • vav 1 guanine nucleotide exchange factor
  • vav proto-oncogene
  • Vav1
  • Vav-1
  • vav-T
  • VAVvav 1 oncogene

Background

The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels (2). As a signaling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein (3). Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol VAV1