After August 17, 2026, Novus Biologicals products and services will no longer be available on this website; you will access all products and services on rndsystems.com. Create your R&D Systems online account today.
The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels (2). As a signaling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein (3). Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response (2).
![Western Blot Vav-1 [p Tyr160] Antibody (751411) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Vav-1_MAB37861_Western_Blot_12193.jpg)
![Immunocytochemistry Vav-1 [p Tyr160] Antibody (751411) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Vav-1_MAB37861_Immunocytochemistry_12236.jpg)
![Simple Western Vav-1 [p Tyr160] Antibody (751411) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/Vav1_MAB37861_Simple_Western_16683.jpg)
