Vav-1 Products

Antibodies
Vav-1 [p Tyr160] Antibody (75 ...
Vav-1 [p Tyr160] Antibody (751411)...
MAB37861
Species: Hu
Applications: WB, Simple Western, ICC/IF
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Vav-1 Antibody
Vav-1 Antibody
NBP1-86867
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Vav-1 Antibody
Vav-1 Antibody
AF3786
Species: Hu
Applications: WB
Host: Sheep Polyclonal
Formulation Catalog # Availability Price  
Lysates
Vav-1 Knockout HeLa Cell Lysa ...
Vav-1 Knockout HeLa Cell Lysate
NBP2-65081
Species: Hu
Applications: WB
Vav-1 Overexpression Lysate
Vav-1 Overexpression Lysate
NBL1-17701
Species: Hu
Applications: WB
Proteins
Vav-1 Recombinant Protein Ant ...
Vav-1 Recombinant Protein Antigen
NBP1-86867PEP
Species: Hu
Applications: AC
Recombinant Human Vav-1 Prote ...
Recombinant Human Vav-1 Protein
NBP2-22938
Species: Hu
Applications: PAGE

Description

The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels (2). As a signaling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein (3). Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response (2).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 7409
Alternate Names
  • vav proto-oncogene
  • proto-oncogene vav
  • oncogene vav
  • VAVvav 1 oncogene
  • vav 1 guanine nucleotide exchange factor

Research Areas for Vav-1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction

Bioinformatics Tool for Vav-1

Discover related pathways, diseases and genes to Vav-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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