TWEAK R/TNFRSF12 Antibody (314636) [Alexa Fluor® 647]

Images

 
There are currently no images for TWEAK R/TNFRSF12 Antibody (FAB16101R).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
314636
Clonality
Monoclonal
Host
Rat
Conjugate
Alexa Fluor 647
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

TWEAK R/TNFRSF12 Antibody (314636) [Alexa Fluor® 647] Summary

Immunogen
E. coli-derived recombinant mouse TWEAK R
Glu28-Trp79
Accession # Q9CR75.1
Specificity
Detects mouse TWEAK R/TNFRSF12 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse (rm) EDA, rmNeogenin, recombinant human TWEAK R, rmOPG, or rmTNF R1 is observed.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TNFRSF12A
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TWEAK R/TNFRSF12 Antibody (314636) [Alexa Fluor® 647]

  • CD266 antigen
  • CD266
  • FGF-inducible 14
  • Fibroblast growth factor-inducible immediate-early response protein 14
  • Fn14
  • FN14tumor necrosis factor receptor superfamily member 12A
  • TNFRSF12
  • TNFRSF12A
  • tumor necrosis factor receptor superfamily, member 12A
  • TWEAK R
  • TWEAKR
  • tweak-receptor
  • type I transmembrane protein Fn14

Background

TNF-related weak inducer of apoptosis receptor (TWEAK R) belongs to the TNF receptor superfamily and is designated TNFRSF12. The gene for TWEAK R was originally identified as a fibroblast growth factor-inducible immediate-early response gene Fn14 in mouse NIH 3T3 fibroblasts (1, 2). Mouse TWEAK R cDNA encodes a 129 amino acid (aa) residues type I transmembrane protein with a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain (1‑3). Human and mouse TWEAK R share 82% aa sequence identity. TWEAK R is the smallest member of the TNF receptor superfamily and contains only one cysteine-rich region in its extracellular domain. The TWEAK R cytoplasmic domain contains one TRAF binding motif which binds TRAFs 1, 2, and 3. TWEAK R binds its ligand TWEAK/TNFSF12 with high affinity to initiate a signal transduction cascade that depending upon the cell type, may lead to a variety of cellular responses including cell death by both caspase-dependent apoptosis and cathepsin B-dependent necrosis, cell proliferation, and angiogenesis (2‑6). In newborn mice, TWEAK R is highly expressed in all tissues examined (heart, intestine, kidney, liver, lung and skin) (1). In adult mice, high TWEAK R expression levels are found in the heart and ovary, while lower expression levels are detected in the lung, kidney, skin. Elevated levels of TWEAK R mRNA were found in human or mouse hepatocellular carcinoma specimens, in regenerating mouse liver and in injured rat arteries (2, 3).

  1. Meighan-Mantha, R. et al. (1999) J. Biol. Chem. 274:33166.
  2. Feng, S. et al. (2000) Am. J. Pathol. 156:1253.
  3. Wiley, S. et al. (2001) Immunity 15:837.
  4. Schneider, P. et al. (1999) Eur. J. Immunol. 29:1785.
  5. Nakayama, M. et al. (2002) J. Immunol. 168:734.
  6. Lynch, C.N. et al. (1999) J. Biol. Chem. 274:8455.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP1-19773
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P
NBP1-91258
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, Fe
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
NB100-56173
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
NB100-56104
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-Fr, IHC-P, IP
AF887
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
MAB208
Species: Hu
Applications: WB, Simple Western, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ICFlow, Neut, ELISA(Sta)
AF1162
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready, Neut
FAB16101R
Species: Mu
Applications: Flow

Publications for TWEAK R/TNFRSF12 Antibody (FAB16101R) (0)

There are no publications for TWEAK R/TNFRSF12 Antibody (FAB16101R).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for TWEAK R/TNFRSF12 Antibody (FAB16101R) (0)

There are no reviews for TWEAK R/TNFRSF12 Antibody (FAB16101R). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for TWEAK R/TNFRSF12 Antibody (FAB16101R) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB16101U
Alexa Fluor 405 FAB16101V
Alexa Fluor 488 FAB16101G
Alexa Fluor 594 FAB16101T
Alexa Fluor 647 FAB16101R
Alexa Fluor 700 FAB16101N
Alexa Fluor 750 FAB16101S

Additional TWEAK R/TNFRSF12 Products

Bioinformatics Tool for TWEAK R/TNFRSF12 Antibody (FAB16101R)

Discover related pathways, diseases and genes to TWEAK R/TNFRSF12 Antibody (FAB16101R). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for TWEAK R/TNFRSF12 Antibody (FAB16101R)

Discover more about diseases related to TWEAK R/TNFRSF12 Antibody (FAB16101R).
 

Pathways for TWEAK R/TNFRSF12 Antibody (FAB16101R)

View related products by pathway.

PTMs for TWEAK R/TNFRSF12 Antibody (FAB16101R)

Learn more about PTMs related to TWEAK R/TNFRSF12 Antibody (FAB16101R).

Blogs on TWEAK R/TNFRSF12

There are no specific blogs for TWEAK R/TNFRSF12, but you can read our latest blog posts.
Coronavirus Brochure

Customers Who Bought This Also Bought

Contact Information

Learn the difference between western blot and simple western

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our TWEAK R/TNFRSF12 Antibody (314636) [Alexa Fluor® 647] and receive a gift card or discount.

Bioinformatics

Gene Symbol TNFRSF12A
Uniprot