TTBK1 Antibody

Images

 
Western Blot: TTBK1 Antibody [NBP1-76989] - Western blot analysis of TTBK1 in Jurkat lysate with TTBK1 antibody at 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: TTBK1 Antibody [NBP1-76989] - Immunofluorescence of TTBK1 in Human Brain cells with TTBK1 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: TTBK1 Antibody [NBP1-76989] - Mouse brain tissue with TTBK1 antibody at 2.5 ug/mL.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TTBK1 Antibody Summary

Immunogen
Antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TTBK1. The immunogen is located within amino acids 1190 - 1240 of TTBK1.
Specificity
Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.
Clonality
Polyclonal
Host
Rabbit
Gene
TTBK1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Theoretical MW
140 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
TTBK1 Peptide (NBP1-76989PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TTBK1 Antibody

  • BDTK
  • Brain-derived tau kinase
  • EC 2.7.11
  • EC 2.7.11.1
  • KIAA1855tau-tubulin kinase 1
  • RP3-330M21.4
  • tau tubulin kinase 1

Background

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TTBK1
Uniprot

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