TSG101 Antibody (1065916) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 1065916
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

TSG101 Antibody (1065916) [Alexa Fluor® 647] Summary

• Immunogen: TSG101 containing synthetic peptide
  Accession # Q99816
• Specificity: Detects TSG101 in direct ELISA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TSG101 Antibody (1065916) [Alexa Fluor® 647]

• ESCRT-I complex subunit TSG101
• TSG10
• TSG101
• tumor susceptibility gene 10
• tumor susceptibility gene 101 protein
• tumor susceptibility gene 101
• tumor susceptibility protein
• VPS23

Background

TSG101 is an essential member of the ESCRT-1 complex which regulates the sorting of ubiquitinated proteins to endosomes, facilitating vesicular trafficking and is implicated in normal development.  It is also involved in regulating transcription, protein sorting, biogenesis of multi-vesicular bodies, and viral budding.  Dysregulation of ESCRT proteins occurs in the development of various human diseases, including many types of cancers and neurodegenerative diseases.  TSG101 is an established cancer-associated gene and truncated aberrantly spliced mRNAs have been reported in various types of cancer. TSG101 is also commonly used as a marker protein for exosomes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.