ARMER Antibody

Images

 
Western Blot: ARMER Antibody [NBP1-77198] - Analysis of ARMER in human bladder cell lysates with anti-ARMER (CT) using NBP1-77198 at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry-Paraffin: ARMER Antibody [NBP1-77198] - Staining of Human bladder tissue at 2 ug/ml.
Immunofluorescence: ARMER Antibody [NBP1-77198] - Immunofluorescence of ARMER in Mouse Intestine cells with ARMER antibody at 2 ug/mL.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

ARMER Antibody Summary

Immunogen
Antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER. The immunogen is located within the last 50 amino acids of ARMER.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ARL6IP1
Purity
Ion exchange chromatography
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5- 2 ug/mL
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunofluorescence 2 ug/ml
Application Notes
ARMER antibody can be used for detection of ARMER by Western blot at 0.5 to 2 mg/ml.
Control Peptide
ARMER Peptide (NBP1-77198PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Ion exchange chromatography

Alternate Names for ARMER Antibody

  • ADP-ribosylation factor-like 6 interacting protein 1
  • ADP-ribosylation factor-like 6 interacting protein
  • AIP1
  • Aip-1
  • apoptotic regulator in the membrane of the endoplasmic reticulum
  • ARL-6-interacting protein 1
  • ARL6IPaip-1
  • ARMER
  • KIAA0069ADP-ribosylation factor-like protein 6-interacting protein 1

Background

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ARL6IP1
Uniprot