Tryptase gamma-1/TPSG1 Antibody (279005) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 279005
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 555

Tryptase gamma-1/TPSG1 Antibody (279005) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human Tryptase gamma ‑1/TPSG1 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) MCPT-1, recombinant human (rh) Tryptase alpha , rmTryptase beta -1, rhTryptase beta -2, or rmTryptase-5 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tryptase gamma-1/TPSG1 Antibody (279005) [Alexa Fluor™ Plus 555]

• EC 3.4.21
• EC 3.4.21.-
• gamma I
• gamma II
• lung tryptase
• mast cell protease II
• mast cell tryptase
• PRSS31skin tryptase
• Serine protease 31
• TMTpituitary tryptase
• TPSG1
• Transmembrane tryptase
• trpA
• tryptase gamma 1
• tryptase gamma I
• tryptase gamma II
• tryptase gamma
• Tryptase gamma1
• Tryptase gamma-1

Background

As mediators of inflammatory and allergic response, mast cells are found throughout the body concentrated near blood vessels in connective tissue and the mucous membranes of the respiratory and gastrointestinal tract (3). Upon activation, human mast cells release granules that are enriched with neutral serine proteases including tryptases, chymase and cathepsin G (4). Tryptase gamma -1, also called transmembrane tryptase, is encoded by TPSG1, one of many serine protease genes clustered in human chromosome 16p13.3 (5). Human Tryptase gamma ‑1 is synthesized as a 321 amino acid preproenzyme with a C-terminal transmembrane anchor (1, 2).

1. Wong, G.W. et al. (1999) J. Biol. Chem. 274:30784.
2. Caughey, G.H. et al. (2000) J. Immunol. 164:6566.
3. Harris, J.L. et al. (2001) J. Biol. Chem. 276:34941.
4. Miller, H.R.P. and A.D. Pemberton (2002) Immunology 105:375.
5. Wong, G.W. et al. (2002) J. Biol. Chem. 277:41906.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.