Species: Hu
Applications: WB, Flow, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IP
Host: Rat Monoclonal
Species: Hu
Applications: WB, IP
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Mu
Applications: Enzyme Activity
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: AC
Description
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq]. COMPLETENESS: complete on the 3' end.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
25823 |
| Alternate Names |
- EC 3.4.21
- EC 3.4.21.-
- gamma I
- gamma II
- lung tryptase
- mast cell protease II
- mast cell tryptase
- PRSS31skin tryptase
- Serine protease 31
- TMTpituitary tryptase
- TPSG1
- Transmembrane tryptase
- trpA
- tryptase gamma 1
- tryptase gamma I
- tryptase gamma II
- tryptase gamma
- Tryptase gamma1
- Tryptase gamma-1
|
