TRPA1 Antibody [HRP]

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Product Details

Summary
Reactivity Hu, Mu, GPSpecies Glossary
Applications WB, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
HRP

TRPA1 Antibody [HRP] Summary

Immunogen
A synthetic peptide made to a region within the N-terminus (residues 1-100) of the human TRPA1 protein. [Swiss-Prot# O75762]
Localization
Membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TRPA1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This TRPA1 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry paraffin embedded sections and Western blot analysis, where a band is seen at ~110 kDa. Immunohistochemistry-Frozen was reported in scientific literature.
Readout System
Publications
Read Publication using NB110-40763H.

Reactivity Notes

Human, mouse and guinea pig. Immunogen sequence has 69% homology to mouse and rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TRPA1 Antibody [HRP]

  • ANKTM1ankyrin-like with transmembrane domains 1
  • Ankyrin-like with transmembrane domains protein 1
  • Transformation-sensitive protein p120
  • transient receptor potential cation channel subfamily A member 1
  • transient receptor potential cation channel, subfamily A, member 1

Background

Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRPA1 Antibody (NB110-40763H)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for TRPA1 Antibody (NB110-40763H) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB110-40763B
DyLight 488 Labeled NB110-40763G
DyLight 550 Labeled NB110-40763R
DyLight 650 Labeled NB110-40763C

Additional TRPA1 Products

Bioinformatics Tool for TRPA1 Antibody (NB110-40763H)

Discover related pathways, diseases and genes to TRPA1 Antibody (NB110-40763H). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for TRPA1 Antibody (NB110-40763H)

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Blogs on TRPA1.

Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

TRPA1: A contributor to itching and inflammation? Scratch that!
Transient receptor potential A1 (TRPA1) is an ion channel found on the plasma membrane of many cell types that functions in diverse sensory processes such as pain and temperature. The TRPA1 ion channel is specifically expressed in nociceptive neurons,...  Read full blog post.

Touch Infographic: From Touch Receptors to the Brain
The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for...  Read full blog post.

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Bioinformatics

Gene Symbol TRPA1