TROY/TNFRSF19 Antibody

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Western Blot: TROY Antibody [NB120-12126] - Analysis of TROY using NB120-12126 in T98G, a human glioblastoma cell line lysate. A protein band of approximately 46 kD is detected.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

TROY/TNFRSF19 Antibody Summary

Immunogen
This rabbit polyclonal antibody was developed by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 29-44, 204-219, and 409-421 of human TROY (Genbank Accession No. AB040434).
Localization
Type I membrane protein (Probable).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TNFRSF19
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
Application Notes
WB: Detects a band of approximately 46 kDa (predicted molecular weight: 50.8 kDa). For optimal results, primary antibody incubations should be performed at room temperature.
Control
TROY/TNFRSF19 Overexpression Lysate

Reactivity Notes

Cross-reacts with Human and Mouse. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for TROY/TNFRSF19 Antibody

  • TAJ
  • TAJ-alpha
  • TAJToxicity and JNK inducer
  • TNFRSF19
  • TRADE
  • TROY
  • TROYtumor necrosis factor receptor superfamily member 19
  • tumor necrosis factor receptor superfamily, member 19

Background

Analysis of EST clones and use of a signal sequence trap screening of the murine brain have lead to identification of a new member of the tumor necrosis factor receptor superfamily designated as TAJ and TROY, respectively. TAJ/TROY is a membrane protein of 423 amino acids with characteristic cysteine-rich motifs in the extracellular domain and a tumor necrosis factor receptor-associated factor (TRAF) 2 binding sequence in the cytoplasmic domain. Human TROY has 78% identity at the amino acid level with mouse TROY. The extracellular domain of TROY has significant homology with that of EDAR (another newly identified receptor belonging to TNF receptor family) that specifies hair follicle fate. The cytoplasmic domain of TAJ is different than other TNF receptor family members. Although its cytoplasmic domain does not contain death domain, TAJ/TROY induced cell death is probably mediated through a caspase-independent pathway. TAJ-induced JNK activation was not blocked by dominant-negative inhibitors of TRAF2, TRAF5, or ASK1, which have been previously implicated in JNK activation via TNFR1 and CD40. However, coimmunoprecipitation assays revealed that TAJ is capable of binding a number of different TRAF family members, and it is possible that TAJ-induced JNKactivation is mediated by an as yet untested TRAF homolog, such as TRAF6. TROY mRNA is highly expressed in brain, prostate and embryo and moderately expressed in the heart, lung, liver.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol TNFRSF19
Entrez
Uniprot