TROP-2 Antibody (sacituzumab) - Humanized - Low Endotoxin, Azide and BSA Free

The endocytosis ratio sacituzumab by human TROP2 HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 70% at antibody concentration of 0.4 nM.

Immobilized human TROP2 His at 2 ug/mL can bind TROP-2 Antibody (sacituzumab) - Humanized, EC50=0.004316 ug/mL.

Human TROP2 HEK293 cells were stained with TROP-2 Antibody (sacituzumab) - Humanized and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.4071 ug/mL.

• Reactivity: Hu
• Applications: ELISA, Flow, Func
• Clone: sacituzumab
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Format: Low Endotoxin, Azide and BSA Free
• Concentration: LYOPH

TROP-2 Antibody (sacituzumab) - Humanized - Low Endotoxin, Azide and BSA Free Summary

• Description: Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.
  
  Also known as 'sacituzumab'.
  
  Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: TROP2
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Gene: TACSTD2
• Purity: Protein A purified
• Endotoxin Note: < 0.001EU/ug,determined by LAL method.

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional

Reactivity Notes

Predicted species reactivity: Mouse

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A purified
• Reconstitution Instructions: Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for TROP-2 Antibody (sacituzumab) - Humanized - Low Endotoxin, Azide and BSA Free

• Cell surface glycoprotein Trop-2
• EGP1
• EGP-1
• epithelial glycoprotein-1
• GA733-1
• GA733-1GP50
• gastrointestinal tumor-associated antigen GA7331
• gp50
• M1S1cell surface glycoprotein TROP2
• Membrane component chromosome 1 surface marker 1
• membrane component, chromosome 1, surface marker 1
• Pancreatic carcinoma marker protein GA733-1
• pancreatic carcinoma marker protein GA7331,40kD glycoprotein, identified by monoclonal GA733
• T16
• TACSTD2
• TROP2
• TROP-2
• TROP2GA7331
• tumor-associated calcium signal transducer 2

Background

TROP2 encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TACSTD2
• Uniprot:
  • P09758()