TROP-2 Products

Description

TROP2 encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. [provided by RefSeq]

Bioinformatics

Entrez	4070 Human 56753 Mouse
Uniprot	AAH09409 Human NM_002353 Human NP_002344 Human NP_002344.2 Human P09758 Human Q8BGV3 Mouse
Product By Gene ID	4070
Alternate Names	Cell surface glycoprotein Trop-2 EGP1 EGP-1 epithelial glycoprotein-1 GA733-1GP50 gastrointestinal tumor-associated antigen GA7331 M1S1cell surface glycoprotein TROP2 Membrane component chromosome 1 surface marker 1 membrane component, chromosome 1, surface marker 1 Pancreatic carcinoma marker protein GA733-1 pancreatic carcinoma marker protein GA7331,40kD glycoprotein, identified by monoclonal GA733 TROP2GA7331 tumor-associated calcium signal transducer 2

Research Areas for TROP-2

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Signal Transduction