TROP-2 Products

Description

TROP2 encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. [provided by RefSeq]

Bioinformatics

Entrez	4070 Human 56753 Mouse
Uniprot	AAH09409 Human P09758 Human NM_002353 Human NP_002344 Human NP_002344.2 Human Q8BGV3 Mouse
Product By Gene ID	4070
Alternate Names	pancreatic carcinoma marker protein GA7331,40kD glycoprotein, identified by monoclonal GA733 Pancreatic carcinoma marker protein GA733-1 membrane component, chromosome 1, surface marker 1 Membrane component chromosome 1 surface marker 1 gastrointestinal tumor-associated antigen GA7331 Cell surface glycoprotein Trop-2 epithelial glycoprotein-1 EGP-1 M1S1cell surface glycoprotein TROP2 GA733-1GP50 TROP2GA7331 EGP1 tumor-associated calcium signal transducer 2

Diseases related to TROP-2

Discover more about diseases related to TROP-2.

Malignant Neoplasms
Neoplasms
Dystrophy
Hereditary Corneal Dystrophy
Carcinoma
Corneal Dystrophy, Lattice Type 3
Corneal Diseases
Adenocarcinoma
Colorectal Cancer
Malignant Neoplasm Of Prostate
Neoplasm Metastasis
Prostatic Neoplasms
Cell Transformation, Neoplastic
Amyloidosis
Malignant Neoplasm Of Breast
Colorectal Neoplasms
Plaque, Amyloid
Metastatic Malignant Neoplasm To The Lymph Node

Pathways for TROP-2

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Pathogenesis
Cell Adhesion
Localization
Methylation
Antibody-dependent Cellular Cytotoxicity
Cell Proliferation
Dna Methylation
Complement-dependent Cytotoxicity
Cell Cycle
Cell Migration
Proteolysis
Immune Response
Reverse Transcription
Embryo Implantation
Cell Growth
Angiogenesis
Rna Interference
Oncogenesis
Cell-cell Adhesion

Research Areas for TROP-2

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Signal Transduction

PTMs for TROP-2

Learn more about PTMs related to TROP-2.

Methylation
Cleavage
Phosphorylation
Glycosylation

Bioinformatics Tool for TROP-2

Discover related pathways, diseases and genes to TROP-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.