TRAM/TICAM2 Antibody Blocking Peptide

Product Discontinued

TRAM/TICAM2 Antibody Blocking Peptide Summary

• Description: A blocking peptide containing 13 amino acids near the carboxy terminus of human TIRP.

  Source: Synthetic

  (Accession #: AAP81748)

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: TICAM2
• Purity: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-77199.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
• Preservative: 0.02% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: N/A

Alternate Names for TRAM/TICAM2 Antibody Blocking Peptide

• MGC129876
• MGC129877
• Putative NF-kappa-B-activating protein 502
• TICAM2
• TICAM-2TIR domain-containing adapter molecule 2
• TIRAP3
• TIRP
• TIRPcytoplasmic adaptor
• toll/interleukin-1 receptor (TIR) domain-containing adapter protein
• Toll/interleukin-1 receptor domain-containing protein
• toll-like receptor adaptor molecule 2
• Toll-like receptor adaptor protein 3
• TRAM
• TRAMNF-kappa-B-activating protein 502
• Trif
• TRIF-related adapter molecule
• TRIF-related adaptor molecule

Background

TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TICAM2