TRAM/TICAM2 Antibody

Product Discontinued

TRAM/TICAM2 Antibody Summary

• Immunogen: Antibody was raised against a peptide corresponding to 16 amino acids at the C-terminus of human TIRP. The immunogen is located within the last 50 amino acids of TIRP.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TICAM2
• Purity: Ion exchange chromatography

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: TIRP antibody can be used for detection of TIRP by Western blot at 0.5 to 2 mg/ml.
• Theoretical MW: 27 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Ion exchange chromatography

Alternate Names for TRAM/TICAM2 Antibody

• MGC129876
• MGC129877
• Putative NF-kappa-B-activating protein 502
• TICAM2
• TICAM-2TIR domain-containing adapter molecule 2
• TIRAP3
• TIRP
• TIRPcytoplasmic adaptor
• toll/interleukin-1 receptor (TIR) domain-containing adapter protein
• Toll/interleukin-1 receptor domain-containing protein
• toll-like receptor adaptor molecule 2
• Toll-like receptor adaptor protein 3
• TRAM
• TRAMNF-kappa-B-activating protein 502
• Trif
• TRIF-related adapter molecule
• TRIF-related adaptor molecule

Background

TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB. Expression of TIRP appears to be essential for TLR4 signalling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TICAM2
• Uniprot:
  • AAP81748(Human)