TRAM/TICAM2 Antibody (757706) [mFluor Violet 500 SE]

• Reactivity: Mu
• Applications: WB
• Clone: 757706
• Clonality: Monoclonal
• Host: Rat
• Conjugate: mFluor Violet 500 SE

TRAM/TICAM2 Antibody (757706) [mFluor Violet 500 SE] Summary

• Immunogen: E. coli-derived recombinant mouse TRAM/TICAM2
  Met1-Ala232
  Accession # Q8BJQ4
• Specificity: Detects mouse TRAM/TICAM2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) TRAM/TICAM2 or rhTRIF/TICAM1 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: TICAM2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TRAM/TICAM2 Antibody (757706) [mFluor Violet 500 SE]

• MGC129876
• MGC129877
• Putative NF-kappa-B-activating protein 502
• TICAM2
• TICAM-2TIR domain-containing adapter molecule 2
• TIRAP3
• TIRP
• TIRPcytoplasmic adaptor
• toll/interleukin-1 receptor (TIR) domain-containing adapter protein
• Toll/interleukin-1 receptor domain-containing protein
• toll-like receptor adaptor molecule 2
• Toll-like receptor adaptor protein 3
• TRAM
• TRAMNF-kappa-B-activating protein 502
• Trif
• TRIF-related adapter molecule
• TRIF-related adaptor molecule

Background

TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TICAM2