TRAIL/TNFSF10 Antibody (55B709.3) - Azide and BSA Free

Western Blot: TRAIL/TNFSF10 Antibody (55B709.3) - Azide and BSA Free [NBP2-80989] - Analysis of TRAIL in Jurkat lysate Image from the standard format of this antibody.

Immunohistochemistry: TRAIL/TNFSF10 Antibody (55B709.3) - Azide and BSA Free [NBP2-80989] - Analysis of TRAIL in human kidney using TRAIL antibody at 5 ug/ml. Image from the standard format of this antibody.

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 55B709.3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1 mg/ml

TRAIL/TNFSF10 Antibody (55B709.3) - Azide and BSA Free Summary

• Immunogen: This monoclonal antibody was raised against a peptide corresponding to amino acids 17-35 of human TRAIL. This peptide sequence has been shown to be involved in TRAIL and DR5 (TRAIL-R2) interaction.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: TNFSF10
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1-2 ug/ml

Reactivity Notes

Predicted to react with Canine and Feline.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: Protein G purified

Alternate Names for TRAIL/TNFSF10 Antibody (55B709.3) - Azide and BSA Free

• Apo-2 ligand
• APO2L
• Apo-2Ltumor necrosis factor (ligand) family, member 10
• APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta
• CD253 antigen
• CD253
• Protein TRAIL
• TL2
• TNF-related apoptosis-inducing ligand
• TNFSF10
• TRAIL
• TRAILTNF-related apoptosis inducing ligand TRAIL
• tumor necrosis factor (ligand) superfamily, member 10
• tumor necrosis factor ligand superfamily member 10

Background

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (6,7). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFSF10