TRAIL/TNFSF10 Products

Antibodies
TRAIL/TNFSF10 Antibody [Uncon ...
TRAIL/TNFSF10 Antibody [Unconjugated]
AF375
Species: Hu
Applications: WB, IHC, B/N
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
TRAIL/TNFSF10 Antibody (75411 ...
TRAIL/TNFSF10 Antibody (75411) [Un...
MAB375
Species: Hu
Applications: IHC, B/N
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
ELISA Kits
Human TRAIL/TNFSF10 ELISA Kit ...
Human TRAIL/TNFSF10 ELISA Kit (Col...
NBP1-82418
Species: Hu
Applications: ELISA
Lysates
TRAIL/TNFSF10 Knockout A549 C ...
TRAIL/TNFSF10 Knockout A549 Cell L...
NBP2-78521
Species: Hu
TRAIL/TNFSF10 Knockout HeLa C ...
TRAIL/TNFSF10 Knockout HeLa Cell L...
NBP2-78539
Species: Hu
TRAIL/TNFSF10 Overexpression ...
TRAIL/TNFSF10 Overexpression Lysate
NBL1-17161
Species: Hu
Applications: WB
Proteins
Recombinant Human TRAIL/TNFSF ...
Recombinant Human TRAIL/TNFSF10 Pr...
375-TL
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human TRAIL/TNFSF ...
Recombinant Human TRAIL/TNFSF10 (E...
375-TEC
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse TRAIL/TNFSF ...
Recombinant Mouse TRAIL/TNFSF10 Pr...
1121-TL
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain". In addition, two decoy receptors for TRAIL have also been identified. These receptors, designated DcR1 and DcR2, lack the death domain. Binding of TRAIL to either of these receptors, therefore, does not transmit the death signal. Thus, these receptors represent a novel way of regulating cell sensitivity to a pro-apoptotic cytokine at the cell surface. TRAIL is expressed predominantly in spleen, lung, and prostate but also in many other tissues.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 8743
Alternate Names
  • APO2L
  • Protein TRAIL
  • Apo-2 ligand
  • CD253 antigen
  • TL2
  • tumor necrosis factor ligand superfamily member 10
  • CD253
  • APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta
  • Apo-2Ltumor necrosis factor (ligand) family, member 10
  • TRAILTNF-related apoptosis inducing ligand TRAIL
  • TNF-related apoptosis-inducing ligand
  • tumor necrosis factor (ligand) superfamily, member 10

Research Areas for TRAIL/TNFSF10

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Signal Transduction
Tumor Suppressors

Bioinformatics Tool for TRAIL/TNFSF10

Discover related pathways, diseases and genes to TRAIL/TNFSF10. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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