TRAIL/TNFSF10 Products

Antibodies
TRAIL/TNFSF10 Antibody [Uncon ...
TRAIL/TNFSF10 Antibody [Unconjugated]
AF375
Species: Hu
Applications: WB, IHC, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
TRAIL/TNFSF10 Antibody (75411 ...
TRAIL/TNFSF10 Antibody (75411) [Un...
MAB375
Species: Hu
Applications: IHC, Neut
Host: Mouse Monoclonal
ELISA Kits
TRAIL/TNFSF10 ELISA Kit
TRAIL/TNFSF10 ELISA Kit
NBP1-82418
Species: Hu
Applications: ELISA
TRAIL/TNFSF10 ELISA Kit [Biot ...
TRAIL/TNFSF10 ELISA Kit [Biotin]
KA0176
Species: Hu
TRAIL/TNFSF10 ELISA Kit [Biot ...
TRAIL/TNFSF10 ELISA Kit [Biotin]
KA0990
Species: Hu
Lysates
TRAIL/TNFSF10 Overexpression ...
TRAIL/TNFSF10 Overexpression Lysat...
H00008743-T01
Species: Hu
Applications: WB
TRAIL/TNFSF10 Overexpression ...
TRAIL/TNFSF10 Overexpression Lysat...
NBL1-17161
Applications: WB
TRAIL/TNFSF10 Overexpression ...
TRAIL/TNFSF10 Overexpression Lysat...
H00008743-T02
Applications: WB
Proteins
TRAIL/TNFSF10 Recombinant Pro ...
TRAIL/TNFSF10 Recombinant Protein
H00008743-P01
Species: Hu
Applications: WB, ELISA, PA
TRAIL/TNFSF10 Recombinant Pro ...
TRAIL/TNFSF10 Recombinant Protein
NBC1-18505
Species: Hu
Applications: PAGE
TRAIL/TNFSF10 Recombinant Pro ...
TRAIL/TNFSF10 Recombinant Protein ...
NBP2-38744PEP
Species: Hu
Applications: AC
RNAi
TRAIL/TNFSF10 RNAi
TRAIL/TNFSF10 RNAi
H00008743-R01
Species: Hu

Description

Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain". In addition, two decoy receptors for TRAIL have also been identified. These receptors, designated DcR1 and DcR2, lack the death domain. Binding of TRAIL to either of these receptors, therefore, does not transmit the death signal. Thus, these receptors represent a novel way of regulating cell sensitivity to a pro-apoptotic cytokine at the cell surface. TRAIL is expressed predominantly in spleen, lung, and prostate but also in many other tissues.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 8743
Alternate Names
  • APO2L
  • Protein TRAIL
  • Apo-2 ligand
  • CD253 antigen
  • TL2
  • tumor necrosis factor ligand superfamily member 10
  • CD253
  • APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta
  • Apo-2Ltumor necrosis factor (ligand) family, member 10
  • TRAILTNF-related apoptosis inducing ligand TRAIL
  • TNF-related apoptosis-inducing ligand
  • tumor necrosis factor (ligand) superfamily, member 10

Research Areas for TRAIL/TNFSF10

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Signal Transduction
Tumor Suppressors

Bioinformatics Tool for TRAIL/TNFSF10

Discover related pathways, diseases and genes to TRAIL/TNFSF10. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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