TRAF-4 Antibody

Images

 
Immunohistochemistry-Paraffin: TRAF-4 Antibody [NB100-56177] - Formalin-fixed, paraffin embedded, normal human mammary epithelial tissue using th antibody. A-C: Strong TRAF4 staining is seen in the luminal epithelial ...read more
Immunoprecipitation: TRAF-4 Antibody [NB100-56177] - The NB100-56177 TRAF4 antibody specifically immunoprecipitates TRAF4. Top: TRAFs 2,3,4,5, and 6 were in vitro translated in the presence of 35S-methionine, and ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, ZeSpecies Glossary
Applications WB, IHC, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

TRAF-4 Antibody Summary

Immunogen
A synthetic peptide corresponding to amino acids 1-17 (MPGFDYKFLEKPKRRLL) of human TRAF4 was used as immunogen; GenBank no. gi|22027622|ref|NP_004286.2|.
Specificity
TRAF4
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TRAF4
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:2000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:1000-1:5000
  • Immunoprecipitation 1:1000-1:5000
Control
TRAF-4 Lysate (NBL1-17244)
Publications
Read Publication using NB100-56177.

Reactivity Notes

Cow, Human, Mouse, Rat, Zebrafish

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.02% Sodium Azide
Purity
Unpurified

Alternate Names for TRAF-4 Antibody

  • CART1
  • CART1RING finger protein 83
  • Cysteine-rich domain associated with RING and Traf domains protein 1
  • Metastatic lymph node gene 62 protein
  • MLN 62
  • MLN62
  • MLN62cysteine-rich domain associated with ring and TRAF domain
  • RNF83malignant 62
  • TNF receptor-associated factor 4
  • TRAF4
  • TRAF-4
  • tumor necrosis receptor-associated factor 4A

Background

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRAF-4 Antibody (NB100-56177)(1)

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Video Protocols

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Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol TRAF4
Entrez