TORC3/CRTC3 Antibody (2069D) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 2069D
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 647

TORC3/CRTC3 Antibody (2069D) [Alexa Fluor® 647] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: E. coli-derived recombinant human TORC3
  Ser425-Asn574
  Accession # Q6UUV7
• Specificity: Detects human TORC3 in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TORC3/CRTC3 Antibody (2069D) [Alexa Fluor® 647]

• CREB regulated transcription coactivator 3
• CRTC3
• FLJ21868
• TORC3
• TORC-3
• TORC3CREB-regulated transcription coactivator 3
• Transducer of CREB protein 3
• transducer of regulated cAMP response element-binding protein (CREB) 3
• Transducer of regulated cAMP response element-binding protein 3
• transducer of regulated CREB protein 3

Background

CREB-Regulated Transcription Coactivator 3 (CRTC3), also known as TORC3, a transcriptional coactivator for CREB1, acts as a coactivator in the SIK/TORC signaling pathway. Dephosphorylated CRTC3 increases the interaction of CREB1 cAMP response element (CRE) sites. CRTC3 activity is important in regulating the expression of genes involved in cellular energy metabolism. Its binding to the HTLV-1 protein Tax enhances HTLV-1 transcription, whereas its binding to cellular Bcl3 inhibits HTLV-1 transcription. CRTC3 polymorphism have been associated with obesity and hypertriglyceridemia. 

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.