TNPO3 Antibody - BSA Free

Western Blot: TNPO3 Antibody [NBP1-76374] - Western blot analysis of TNPO3 expression in Jurkat cell lysate with TNPO3 antibody at (A) 1 and (B) 2 ug/ml.

Western Blot: TNPO3 Antibody [NBP1-76374] - Rat liver tissue lysate with TNPO3 antibody at (A) 1 and (B) 2 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

TNPO3 Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3. The immunogen is located within amino acids 220 - 270 of TNPO3. Amino Acid Squence: EVLQQDKSTSSNLHEAASD
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TNPO3
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1-2 ug/ml
• Theoretical MW: 96 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control Peptide:

  TNPO3 Peptide (NBP1-76374PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for TNPO3 Antibody - BSA Free

• imp12
• MTR10A
• transportin 3
• transportin-3

Background

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNPO3
• Uniprot:
  • EAW83708(Human)