TNIP3 Antibody


Western Blot: TNIP3 Antibody [NBP1-77365] - Human spleen tissue lysate with TNIP3 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry-Paraffin: TNIP3 Antibody [NBP1-77365] - Mouse spleen tissue with TNIP3 antibody at 5 ug/ml.

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
1 mg/ml

Order Details

TNIP3 Antibody Summary

Antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified


Reactivity Notes

Human, Mouse

Alternate Names for TNIP3 Antibody

  • A20
  • A20-binding inhibitor of NF-kappa-B activation 3
  • ABIN3
  • ABIN-3ABIN-3 beta
  • FLJ21162
  • LINDListeria induced
  • Listeria-induced gene protein
  • TNFAIP3 interacting protein 3
  • TNFAIP3-interacting protein 3 beta
  • TNFAIP3-interacting protein 3
  • TNIP3 beta


The nuclear factor NF-kappaB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kappaB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kappaB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kappaB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kappaB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kappaB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


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Contact Information

Product PDFs


Gene Symbol TNIP3

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