TNIP3 Antibody

Images

 
Western Blot: TNIP3 Antibody [NBP1-77365] - Human spleen tissue lysate with TNIP3 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry-Paraffin: TNIP3 Antibody [NBP1-77365] - Mouse spleen tissue with TNIP3 antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TNIP3 Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ABIN3. The immunogen is located within the last 50 amino acids of ABIN3.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TNIP3
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
TNIP3 Peptide (NBP1-77365PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TNIP3 Antibody

  • A20
  • A20-binding inhibitor of NF-kappa-B activation 3
  • ABIN3
  • ABIN-3ABIN-3 beta
  • FLJ21162
  • LINDListeria induced
  • Listeria-induced gene protein
  • TNFAIP3 interacting protein 3
  • TNFAIP3-interacting protein 3 beta
  • TNFAIP3-interacting protein 3
  • TNIP3 beta

Background

The nuclear factor NF-kappaB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kappaB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kappaB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kappaB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kappaB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kappaB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TNIP3
Uniprot