TNF RI/TNFRSF1A Antibody (H398) [FITC] Summary
The immunogen for this antibody is. The exact immunogenic sequence is proprietary.
Protein A purified
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
FITC (A=495, E=519)
PBS (pH 7.2) and 1.0% BSA
0.05% Sodium Azide
Protein A purified
- Flow Cytometry 10-20 ug/ml
Alternate Names for TNF RI/TNFRSF1A Antibody (H398) [FITC]
- CD120a antigen
- tumor necrosis factor binding protein 1
- Tumor necrosis factor receptor 1
- tumor necrosis factor receptor 1A isoform beta
- tumor necrosis factor receptor superfamily member 1A
- tumor necrosis factor receptor superfamily, member 1A
- tumor necrosis factor receptor type 1
- Tumor necrosis factor receptor type I
- tumor necrosis factor-alpha receptor
The monoclonal antibody HM104 recognizes the extracellular part of the Tumor Necrosis Factor Receptor type I (TNF-RI) of the membrane-bound as well as the soluble receptor. TNF-RI (~55-60 kDa) is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation, and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-R1 and TNF-R2, which have both distinct and overlapping downstream signaling cascades. Induction of cytotoxicity and other functions are mediated largely via TNF-RI. TNF-R1 is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-R2 is efficiently activated only by the membrane bound form of TNF-alpha. TNF-R1 signaling is initiated when trimeric TNF-alpha binds TNF-R1 receptors. Subsequent TNF-R1 trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor of Apoptosis Protein 1 (cIAP1), TNF Receptor Associated Factor 2 (TRAF2), and likely TRAF5. Studies with TNF-R1-deficient mice indicate that TNF-R1 mediates most of the proliferation, pro-inflammatory, and apoptosis-activating pathways.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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