Thimet Oligopeptidase/THOP1 Antibody (4D6) [DyLight 650]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Pm, RbSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clone
4D6
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

Thimet Oligopeptidase/THOP1 Antibody (4D6) [DyLight 650] Summary

Immunogen
A synthetic peptide corresponding to residues 56-72 of human Thimet Oligopeptidase. [UniProt# P52888]
Localization
Cytoplasmic
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
THOP1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Thimet Oligopeptidase (4D6) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot, where a band is seen at ~80 kDa. For IHC-P, this antibody has been tested in human, monkey, and rat brain and testis. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, mouse, rat, rabbit, and monkey.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Thimet Oligopeptidase/THOP1 Antibody (4D6) [DyLight 650]

  • EC 3.4.24
  • EC 3.4.24.15
  • Endopeptidase 24.15
  • EP24.15
  • MEPD_HUMAN
  • MP78
  • thimet oligopeptidase 1
  • thimet oligopeptidase
  • THOP1
  • TOP

Background

A steady-state level of amyloid beta-peptide (Abeta) represents a balance between its biosynthesis from the amyloid precursor protein (APP) through the action of the beta and gamma-secretases and its catabolism by a variety of proteolytic enxymes. Thimet Oligopeptidase (THOP1) has been shown to promote A-beta degradation. It has also been shown to play a role in antigen presentation, metabolism of neuropeptides under 20 amino acids, and cytoplasmic peptide degradation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB400-146B
DyLight 350 Labeled NB400-146UV
DyLight 405 Labeled NB400-146V
DyLight 488 Labeled NB400-146G
DyLight 550 Labeled NB400-146R
DyLight 680 Labeled NB400-146FR
DyLight 755 Labeled NB400-146IR
FITC Labeled NB400-146F
HRP Labeled NB400-146H

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Diseases for Thimet Oligopeptidase/THOP1 Antibody (NB400-146C)

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Bioinformatics

Gene Symbol THOP1
Entrez