TGF-beta RII Antibody [Allophycocyanin]

Human peripheral blood lymphocytes were stained with Goat Anti-Human TGF-beta RII APC-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB2411A, filled histogram) or isotype control antibody (Catalog # IC108A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Extrafacial expression of T beta RII on malignant breast cancer cell-derived EVs&its regulation by TGF-beta . f FACS analysis&quantification of the %age of T beta RII positive (T beta RII+) EVs from different breast cancer cell lines (left panel). n = 3 biological replicates per group (right panel). The %age was referred to as the %age of beads with T beta RII+ EVs. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/35915084), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu
• Applications: Flow
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Allophycocyanin

TGF-beta RII Antibody [Allophycocyanin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TGF‑ beta RII
  Ile24-Asp159
  Accession # P37173.2
• Specificity: Detects human TGF-beta RII in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse (rm) TGF‑ beta RII and less than 1% cross-reactivity with recombinant human TGF-beta RIII and rmTGF-beta RI is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TGFBR2
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta RII Antibody [Allophycocyanin]

• AAT3
• EC 2.7.11
• EC 2.7.11.30
• FAA3
• HNPCC6
• LDS1B
• LDS2B
• MFS2
• RIIC
• TAAD2
• tbetaR-II
• TGF-beta receptor type II
• TGF-beta receptor type IIB
• TGF-beta receptor type-2
• TGF-beta RII
• TGF-beta type II receptor
• TGFbetaRII
• TGFbeta-RII
• TGFBR2
• TGF-bRII
• TGFR-2
• transforming growth factor beta receptor type IIC
• transforming growth factor, beta receptor II (70/80kDa) isoform 1
• transforming growth factor, beta receptor II (70/80kDa) isoform 2
• transforming growth factor, beta receptor II (70/80kDa)
• transforming growth factor, beta receptor II (70-80kD)
• Transforming growth factor-beta receptor type II

Background

TGF beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF beta RII interacts with TGF beta RI to form the heteromeric signaling complex thattransduces TGF beta signals. A splice variant of the type II receptor, TGF beta RIIb, containing a 25 amino acid residue insertion near the Nterminus of the mature protein has also been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TGF-beta RII Antibody (FAB2411A)(2)

Publications using FAB2411A

• S Su, AR Guntur, DC Nguyen, SS Fakory, CC Doucette, C Leech, H Lotana, M Kelley, J Kohli, J Martino, S Sims-Lucas, L Liaw, C Vary, CJ Rosen, AC Brown A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome Cell Rep, 2018-12-11;25(11):3215-3228.e9. 2018-12-11 [PMID: 30540952] (Flow Cytometry, Mouse)
• KW Cheung, T Wu, SF Ho, YC Wong, L Liu, H Wang, Z Chen ??CD4effector/effector memory T cells differentiate into productively and latently infected central memory T cells by TGF?1 during HIV-1 infection J. Virol., 2018-03-28;0(0):. 2018-03-28 [PMID: 29386290] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: TGFBR2
• Uniprot:
  • P37173.2()