TGF-beta RII Products

Description

TGF beta Receptor II is a total of three members of the TGFbeta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor (TGFbeta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFbeta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFbeta type I receptor proteins designated ALK-5 (TbetaR-1) and TSR-1, respectively.

Bioinformatics

Entrez	21808 Mouse 21813 Mouse 7048 Human 81809 Rat 81810 Rat
Uniprot	NM_001024847 Human NM_003242 Human NP_001020018 Human NP_003233.4 Human P37173 Human Q62312 Mouse
Product By Gene ID	7048
Alternate Names	AAT3 EC 2.7.11 EC 2.7.11.30 FAA3 HNPCC6 LDS1B LDS2B MFS2 RIIC TAAD2 TbetaR-II tbetaR-II TGF-beta receptor type II TGF-beta receptor type IIB TGF-beta receptor type-2 TGF-beta type II receptor TGFbeta-RII TGFR-2 transforming growth factor beta receptor type IIC transforming growth factor, beta receptor II (70/80kDa) isoform 1 transforming growth factor, beta receptor II (70/80kDa) isoform 2 transforming growth factor, beta receptor II (70/80kDa) transforming growth factor, beta receptor II (70-80kD) Transforming growth factor-beta receptor type II

Research Areas for TGF-beta RII

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cell Cycle and Replication