TGF-beta RII Products

Description

TGF beta Receptor II is a total of three members of the TGFbeta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor (TGFbeta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFbeta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFbeta type I receptor proteins designated ALK-5 (TbetaR-1) and TSR-1, respectively.

Bioinformatics

Product By Gene ID

7048

Alternate Names

AAT3 EC 2.7.11 EC 2.7.11.30 FAA3 HNPCC6 LDS1B LDS2B MFS2 RIIC TAAD2 tbetaR-II TGF-beta receptor type II TGF-beta receptor type IIB TGF-beta receptor type-2 TGF-beta RII TGF-beta type II receptor TGFbetaRII TGFbeta-RII TGFBR2 TGF-bRII TGFR-2 transforming growth factor beta receptor type IIC transforming growth factor, beta receptor II (70/80kDa) isoform 1 transforming growth factor, beta receptor II (70/80kDa) isoform 2 transforming growth factor, beta receptor II (70/80kDa) transforming growth factor, beta receptor II (70-80kD) Transforming growth factor-beta receptor type II

Research Areas for TGF-beta RII

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cell Biology
Cell Cycle and Replication