TGF-beta Antibody [Unconjugated] - Pan Specific


Porcine TGF-beta 1 (Catalog # 101-B1) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced proliferation in the HT-2 mouseT cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse more
TGF‑ beta was detected in immersion fixed paraffin-embedded sections of human prostate tissue using Rabbit Anti-TGF‑ beta Pan Specific Polyclonal Antibody (Catalog # AB-100-NA) at 3 µg/mL for 1 hour at more

Product Details

Reactivity All-MultiSpecies Glossary
Applications WB, IHC, B/N

Order Details

TGF-beta Antibody [Unconjugated] - Pan Specific Summary

Recombinant human TGF‑ beta 1, porcine platelet-derived TGF‑ beta 1.2, porcine platelet-derived TGF‑ beta 2, and recombinant amphibian TGF‑ beta 5
Detects TGF-beta 1, TGF-beta 1.2, TGF-beta 2, TGF-beta 3, and TGF-beta 5 in direct ELISAs and Western blots.
Purity Statement
Protein A or G purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunohistochemistry 3-15 ug/mL
  • Neutralization 5 ug/mL
  • Western Blot 1 ug/mL
Read Publications using
AB-100-NA in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
No Preservative
Reconstitution Instructions
Reconstitute at 1 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta Antibody [Unconjugated] - Pan Specific

  • CED
  • DPD1
  • LAP
  • TGFB
  • TGFB1
  • TGFbeta
  • TGF-beta
  • transforming growth factor beta 1


TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure. TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-beta isoform has some non-redundant functions; for TGF-beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation. Human TGF-beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein. A furin-like convertase processes the proprotein to generate an N-terminal 249 aa latency-associated peptide (LAP) and a C-terminal 112 aa mature TGF- beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain non-covalently associated after secretion, forming the small latent TGF-beta 1 complex. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix. TGF-beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins. Mature human TGF-beta 1 shares 100% aa identity with pig, dog and cow TGF-beta 1, and 99% aa identity with mouse, rat and horse TGF-beta 1. It demonstrates cross-species activity. TGF-beta 1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-beta RI (also called activin receptor-like kinase (ALK) -5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription. Contributions of the accessory receptors betaglycan (also known as TGF-beta RIII) and endoglin, or use of Smad-independent signaling pathways, allow for disparate actions observed in response to TGF-beta in different contexts.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TGF-beta Antibody (AB-100-NA)(55)

We have publications tested in 7 confirmed species: Human, Mouse, Rat, Bovine, Goat, Mink, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 9 applications: Bioassay, Blocking, Cell Culture, Electron Microscopy, ICC, IHC, IHC-P, Neutralization, Western Blot.

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Electron Microscopy
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Filter By Species
Primate - Macaca mulatta (Rhesus Macaque)
All Species
Showing Publications 1 - 10 of 55. Show All 55 Publications.
Publications using AB-100-NA Applications Species
NM Kamal, MA Hamouda, N Abdelgawad Expression of TGF-beta and MMP-2 in hereditary gingival fibromatosis epithelial cells. A possible contribution of the epithelium to its pathogenesis Journal of oral biology and craniofacial research, 2022;12(5):617-622. 2022 [PMID: 35989975] (IHC, Human) IHC Human
J Gokavi, S Sadawarte, A Shelke, U Kulkarni-K, M Thakar, V Saxena Inhibition of miR-155 Promotes TGF-beta Mediated Suppression of HIV Release in the Cervical Epithelial Cells Viruses, 2021;13(11):. 2021 [PMID: 34835072] (Neutralization, Human) Neutralization Human
A Shi, J Li, X Qiu, M Sabbah, S Boroumand, TC Huang, C Zhao, A Terzic, A Behfar, SL Moran TGF-&amp;beta loaded exosome enhances ischemic wound healing in vitro and in vivo Theranostics, 2021;11(13):6616-6631. 2021 [PMID: 33995680] (Neutralization, Human) Neutralization Human
YE Choi, MJ Song, M Hara, K Imanaka-Yo, DH Lee, JH Chung, ST Lee Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging Int J Mol Sci, 2020;21(22):. 2020 [PMID: 33217999] (Neutralization, Human) Neutralization Human
L Panahipour, Z Kargarpour, M Laggner, M Mildner, HJ Ankersmit, R Gruber TGF-&amp;beta in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis Int J Mol Sci, 2020;21(22):. 2020 [PMID: 33202935] (Neutralization, Mouse) Neutralization Mouse
L Ji, T Wang, L Tian, H Song, M Gao Roxatidine inhibits fibrosis by inhibiting NF?kappaB and MAPK signaling in macrophages sensing breast implant surface materials Mol Med Rep, 2019;0(0):. 2019 [PMID: 31746427] (Neutralization, Mouse) Neutralization Mouse
R García-Roc, A Monroy-Gar, J Hernández-, B Weiss-Stei, V Gutiérrez-, M Del Carmen, LR Ávila-Ibar, CA Don-López, DB Torres-Pin, M de Lourdes Cervical cancer cells produce TGF-?1 through the CD73-adenosine pathway and maintain CD73 expression through the autocrine activity of TGF-?1 Cytokine, 2019;118(0):71-79. 2019 [PMID: 30301599] (Neutralization, Human) Neutralization Human
J Zheng, Y Mei, P Xiang, G Zhai, N Zhao, C Xu, M Liu, Z Pan, K Tang, D Jia DNA methylation affects metastasis of renal cancer and is associated with TGF-?/RUNX3 inhibition Cancer Cell Int., 2018;18(0):56. 2018 [PMID: 29651226] (Western Blot, Human) Western Blot Human
M Hulsmans, HB Sager, JD Roh, M Valero-Muñ, NE Houstis, Y Iwamoto, Y Sun, RM Wilson, G Wojtkiewic, B Tricot, MT Osborne, J Hung, C Vinegoni, K Naxerova, DE Sosnovik, MR Zile, AD Bradshaw, R Liao, A Tawakol, R Weissleder, A Rosenzweig, FK Swirski, F Sam, M Nahrendorf Cardiac macrophages promote diastolic dysfunction J. Exp. Med., 2018;0(0):. 2018 [PMID: 29339450] (Cell Culture, Mouse) Cell Culture Mouse
J Xiao, K Yu, M Li, C Xiong, Y Wei, Q Zeng The IL-2/Anti-IL-2 Complex Attenuates Cardiac Ischaemia-Reperfusion Injury Through Expansion of Regulatory T Cells Cell. Physiol. Biochem., 2017;44(5):1810-1827. 2017 [PMID: 29224017] (Neutralization, Mouse) Neutralization Mouse
Show All 55 Publications.

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Blogs on TGF-beta.

Neurovascular signaling for repair enhances brain metastasis
By Jamshed Arslan, Pharm. D., PhD. Stroke    is a leading cause of mortality and morbidity worldwide. Cellular players – neurons, astrocytes, endothelial and stromal cells – involved in post-stroke repair t...  Read full blog post.

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling
By Jamshed Arslan Pharm.D. Gastric carcinoma is the second leading cause of cancer-related deaths worldwide. One of the key features of gastric carcinoma is acidosis, which promotes growth and metastasis of gastric ...  Read full blog post.

You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers
By Jamshed Arslan Pharm.D. Natural killer (NK) cells are lymphocytes of the innate immune system that were first discovered for their “natural” ability to kill cancer cells. To use NK cells as anti-cancer therapy, t...  Read full blog post.

TGF-beta for treating degenerative intervertebral disc disease
By Jamshed Arslan Pharm.D. Our upright posture and balance depend on a jelly-like material, called nucleus pulposus (NP), in the middle of intervertebral discs. NP cells protect us from disc degeneration by maintain...  Read full blog post.

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma
By Jamshed Arslan Pharm.D. Multiple myeloma (MM) is a cancer of antibody-producing plasma cells. The bone marrow (BM) of MM patients is hypoxic, and MM cells overexpress many cancerous genes that are regulated by hy...  Read full blog post.

TGF-beta RIII - A multi-functional regulator of the TGF-beta signaling pathway
Transforming growth factor-beta receptor III (TGF-beta RIII) is one of three receptors for the secreted growth factor TGF-beta. Unlike type I and type II TGF-beta receptors, TGF-beta RIII does not participate directly in the propagation of intracel...  Read full blog post.

CCR2 or CD192
CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulate...  Read full blog post.

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Gene Symbol TGFB1