TGF-beta 1 Antibody (141322) [Unconjugated]

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Product Details

Summary
Reactivity All-MultiSpecies Glossary
Applications WB
Clone
141322
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

TGF-beta 1 Antibody (141322) [Unconjugated] Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human TGF‑ beta 1
Specificity
Detects multiple species of TGF-beta 1 in direct ELISAs and Western blots. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF‑ alpha , rhTGF‑ beta 2, rhTGF‑ beta 3, rhTGF‑ beta 5, rhLAP (TGF‑ beta 1), rhART, rhNeurturin, or recombinant mouse TRANCE.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
TGFB1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB2401 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta 1 Antibody (141322) [Unconjugated]

  • CEDLAP
  • DPD1
  • latency-associated peptide
  • TGF beta
  • TGF beta1
  • TGFB
  • TGFB1
  • TGF-beta 1 protein
  • TGFbeta 1
  • TGF-beta 1
  • TGFbeta
  • TGF-beta-1
  • transforming growth factor beta-1
  • transforming growth factor, beta 1

Background

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TGF-beta 1 Antibody (MAB2401)(11)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Porcine, Primate - Pan troglodytes (Chimpanzee).

We have publications tested in 3 applications: Neutralization, Neutralization Control, Western Blot.


Filter By Application
Neutralization
(4)
Neutralization Control
(1)
Western Blot
(1)
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Human
(3)
Mouse
(1)
Rat
(1)
Porcine
(1)
Primate - Pan troglodytes (Chimpanzee)
(1)
All Species
Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using MAB2401 Applications Species
J Liu, S Zhu, L Zeng, J Li, DJ Klionsky, G Kroemer, J Jiang, D Tang, R Kang DCN released from ferroptotic cells ignites AGER-dependent immune responses Autophagy, 2021-12-29;0(0):1-14. 2021-12-29 [PMID: 34964698] (Western Blot, Human) Western Blot Human
Guang Liu, Courtney M. Shea, Juli E. Jones, Gavrielle M. Price, William Warren, Elisabeth Lonie et al. Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells American Journal of Physiology-Renal Physiology 10/1/2020 [PMID: 32865013]
Donna Mancini, Juan Monteagudo, Mayte Suárez-Fariñas, Jeffrey Bander, Rohan Varshney, Juana Gonzalez et al. New methodologies to accurately assess circulating active transforming growth factor-beta 1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices Translational Research 2/1/2018 [PMID: 29175264]
J Laurence, S Elhadad, T Robison, H Terry, R Varshney, S Woolington, S Ghafoory, ME Choi, J Ahamed HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-?1 and can be suppressed by exogenous carbon monoxide PLoS ONE, 2017-10-31;12(10):e0187185. 10/31/2017 [PMID: 29088262]
Cai P, Kovacs L, Dong S et al. BMP4 inhibits PDGF-induced proliferation and collagen synthesis via PKA-mediated inhibition of calpain-2 in pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 5/1/2017 [PMID: 28235949]
Onica Le Le Gendre, Ayisha Sookdeo, Stephie-Anne Duliepre, Matthew Utter, Maria Frias, David A. Foster Suppression of AKT Phosphorylation Restores Rapamycin-Based Synthetic Lethality in SMAD4-Defective Pancreatic Cancer Cells Molecular Cancer Research 5/1/2013 [PMID: 23443316]
Zhu Y, Colak T, Shenoy M, Liu L, Mehta K, Pai R, Zou B, Xie X, Pasricha P Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis. Mol Pain, 2012-09-11;8(0):65. 2012-09-11 [PMID: 22963239] (Neutralization Control, Rat) Neutralization Control Rat
Alexander S, Watt F, Sawaji Y, Hermansson M, Saklatvala J Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB. Arthritis Rheum., 2007-11-01;56(11):3715-25. 2007-11-01 [PMID: 17968943] (Neutralization, Human, Porcine) Neutralization Human, Porcine
Bayry J, Triebel F, Kaveri SV, Tough DF Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J. Immunol., 2007-04-01;178(7):4184-93. 2007-04-01 [PMID: 17371975] (Neutralization, Human) Neutralization Human
Manigold T, Shin EC, Mizukoshi E, Mihalik K, Murthy KK, Rice CM, Piccirillo CA, Rehermann B Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood, 2006-02-14;107(11):4424-32. 2006-02-14 [PMID: 16478885] (Neutralization, Primate - Pan troglodytes (Chimpanzee)) Neutralization Primate - Pan troglodytes (Chimpanzee)
Show All 11 Publications.

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Product General Protocols

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Secondary Antibodies

 

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Blogs on TGF-beta 1.

TGF-beta 1 - a versatile signaling molecule with roles in development and disease
The transforming growth factor-beta (TGF-beta) family consists of a wide variety of signaling proteins with roles in development. TGF-beta signaling controls growth, differentiation, and immune responses and is often misregulated in cancer. TGF-beta ...  Read full blog post.

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Bioinformatics

Gene Symbol TGFB1