Tensin 4/CTEN Antibody (684524) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 684524
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

Tensin 4/CTEN Antibody (684524) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human Tensin 4/CTEN
  Ser2-Gln107
  Accession # Q8IZW8
• Specificity: Detects human Tensin 4/CTEN in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tensin 4/CTEN Antibody (684524) [Alexa Fluor® 594]

• CTEN
• CTENC terminal tensin like
• C-terminal tensin-like protein
• FLJ14950
• Tensin 4
• tensin-4
• TNS4

Background

CTEN, also known as Tensin 4, is a 90 kDa cytoplasmic protein that is associated with focal adhesions in epithelial cells and is upregulated in several carcinomas. It promotes tumorigenesis by disrupting the attachment of focal adhesions to the cytoskeleton, promoting epithelial-mesenchymal transition, and binding nuclear beta‑Catenin. CTEN is cleaved by Caspase-3 at Asp570-Ser571 during apoptosis. It contains a serine-rich region (aa 168-324), one SH2 domain (aa 449-556), and a phosphatase domain (aa 548-714). Within aa 1-107, human CTEN shares 62% and 59% aa sequence identity with mouse and rat CTEN, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.