STAM 1, 2 Antibody - Azide and BSA Free

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: LYOPH

STAM 1, 2 Antibody - Azide and BSA Free Summary

• Description: Novus Biologicals Sheep STAM 1, 2 Antibody - Azide and BSA Free (NBP1-30592) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A synthetic peptide from the internal part of human STAM 1, 2 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many species including rat, mouse, zebra fish and xenopus.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: STAM
• Purity: Ammonium sulfate precipitation

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 10-50 ug/ml
  • Immunohistochemistry-Frozen 10-50 ug/ml
  • Immunohistochemistry-Paraffin 10-50 ug/ml
  • Western Blot 10-50 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from PBS (1x)
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Ammonium sulfate precipitation
• Reconstitution Instructions: Reconstitute 0.5 mg size in 0.5 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the 0.1 mg size is provided in reconstituted format.

Alternate Names for STAM 1, 2 Antibody - Azide and BSA Free

• DKFZp686J2352
• HSE1 homolog
• signal transducing adapter molecule 1
• signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
• STAM1STAM-1

Background

STAM1: ; FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking as well as in T-cell development.; SUBUNIT: Heterodimer. Composed of STAM1 and HGS/HRS. Also interacts directly with STAMBP/AMSH.; TISSUE SPECIFICITY: Ubiquitously expressed.; STAM2:; FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development.; SUBUNIT: Heterodimer or heterotrimer. At least composed of STAM2 and HGS/Hrs. EPS15 can be part of the complex. Interacts directly with STAMBP/AMSH, JAK2 and JAK3. Also interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts directly with CBX5 via the PxVxL motif. Interacts with VPS37C.; TISSUE SPECIFICITY: Ubiquitously expressed.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: STAM
• Entrez:
  • 8027(Human)