STAM 1, 2 Products

Antibodies
STAM 1, 2 Antibody
STAM 1, 2 Antibody
NBP1-30592
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-Fr, IHC-P
Host: Sheep Polyclonal

Description

STAM1: ; FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking as well as in T-cell development.; SUBUNIT: Heterodimer. Composed of STAM1 and HGS/HRS. Also interacts directly with STAMBP/AMSH.; TISSUE SPECIFICITY: Ubiquitously expressed.; STAM2:; FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development.; SUBUNIT: Heterodimer or heterotrimer. At least composed of STAM2 and HGS/Hrs. EPS15 can be part of the complex. Interacts directly with STAMBP/AMSH, JAK2 and JAK3. Also interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts directly with CBX5 via the PxVxL motif. Interacts with VPS37C.; TISSUE SPECIFICITY: Ubiquitously expressed.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Product By Gene ID 8027
Alternate Names
  • signal transducing adapter molecule 1
  • HSE1 homolog
  • DKFZp686J2352
  • STAM1STAM-1
  • signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

PTMs for STAM 1, 2

Learn more about PTMs related to STAM 1, 2.

Ubiquitination
Phosphorylation
Ribosylation
Cleavage
Nitration

Bioinformatics Tool for STAM 1, 2

Discover related pathways, diseases and genes to STAM 1, 2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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