SR-AI/MSR Antibody [Unconjugated]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, B/N
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Conjugate Size Price
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SR-AI/MSR Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse SR-AI/MSR
Trp79-Ser454
Accession # AAA39747
Specificity
Detects mouse SR-A1/MSR in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
MSR1
Purity Statement
Antigen Affinity-purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Blockade of Receptor-ligand Interaction
Publications
Read Publications using
AF1797 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SR-AI/MSR Antibody [Unconjugated]

  • CD204 antigen
  • CD204
  • Macrophage acetylated LDL receptor I and II
  • macrophage scavenger receptor 1
  • macrophage scavenger receptor type III
  • MSR1
  • phSR1
  • phSR2
  • SCARA1
  • SCARA1macrophage scavenger receptor types I and II
  • Scavenger receptor class A member 1
  • scavenger receptor class A, member 1
  • SR-A
  • SRAI
  • SR-AI

Background

The scavenger receptor (SR) family comprises a group of functionally defined membrane receptors that share the common ability to bind and internalize modified forms of Low Density Lipoproteins (mLDL) (1 - 3). Family members are classified alphabetically. The A class include four proteins: the three subtypes of SR-A (AI, AII, and AIII) that are generated by alternative splicing of the same gene, and a structurally similar protein named MARCO (4). All A class SRs are multidomain trimeric type II membrane proteins. SR-AI has an N-terminal cytoplasmic domain, a transmembrane domain, a spacer domain, an alpha -helical coiled coil, a collagen-like domain and a C-terminal cysteine-rich domain. SR-A is expressed by most tissue macrophages, dendritic cells and Kupffer cells. It is also highly expressed by microglia in neonatal as well as Alzheimer’ Disease brains. SR-AI binds a broad range of polyanionic ligands including modified proteins (e.g. Oxidized, acetylated or maleylated LDL, Advanced glycation end-product proteins), polyribonucleotides (polyguanosine and polyinosine), polysaccharides (dextran sulfate, fucoidan), phospholipids (phosphatidylserine), bacterial products (lipopolysaccharide and lipoteichoic acid) and selected chemical compounds (silica, crocidolite asbestos). The ligand-binding region has been localized to a positively charged region in the carboxyl end of the collagen-like domain. Based on its ligand binding characteristics, SR-AI is implicated in many physiological and pathophysiological functions. Studies using SR-A knockout mouse have also suggested roles of SR-A in atherogenesis, host defense and innate immunity, acquired immune responses, macrophage adhesion, and phagocytosis of apoptotic cells (1 - 3).

  1. Daugherty, A. et al. (2000) Curr. Opin. Cardiovasc. Pulm. Ren. Invest. Drugs 2:223.
  2. Platt, N. and S. Gordon (2001) J. Clin. Invest. 108:649.
  3. Platt, N. and S. Gordon (1998) Chem. Biol. 5:R193.
  4. Elomaa, O. et al. (1995) Cell 80:603.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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AF1797
Species: Mu
Applications: WB, B/N

Publications for SR-AI/MSR Antibody (AF1797)(10)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Flow Cytometry, In Vivo, Neutralization, Western Blot.


Filter By Application
Flow Cytometry
(2)
In Vivo
(1)
Neutralization
(3)
Western Blot
(4)
All Applications
Filter By Species
Mouse
(10)
All Species
Showing Publications 1 - 10 of 10.
Publications using AF1797 Applications Species
A Kitaura, T Nishinaka, S Hamasaki, OF Hatipoglu, H Wake, M Nishibori, S Mori, S Nakao, H Takahashi Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages PLoS ONE, 2021;16(1):e0245957. 2021 [PMID: 33493233] (Neutralization, Mouse) Neutralization Mouse
F Hu, X Jiang, C Guo, Y Li, S Chen, W Zhang, Y Du, P Wang, X Zheng, X Fang, X Li, J Song, Y Xie, F Huang, J Xue, M Bai, Y Jia, X Liu, L Ren, X Zhang, J Guo, H Pan, Y Su, H Yi, H Ye, D Zuo, J Li, H Wu, Y Wang, R Li, L Liu, XY Wang, Z Li Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study Nat Commun, 2020;11(1):1911. 2020 [PMID: 32312978] (In Vivo, Mouse) In Vivo Mouse
S Hamasaki, T Kobori, Y Yamazaki, A Kitaura, A Niwa, T Nishinaka, M Nishibori, S Mori, S Nakao, H Takahashi Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified advanced glycation end product-protein phagocytosis Sci Rep, 2018;8(1):5901. 2018 [PMID: 29651042] (Neutralization, Mouse) Neutralization Mouse
S Komine, K Akiyama, E Warabi, S Oh, K Kuga, K Ishige, S Togashi, T Yanagawa, J Shoda Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis Sci Rep, 2017;7(1):11977. 2017 [PMID: 28931917] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Bonilla D, Bhattacharya A, Sha Y, Xu Y, Xiang Q, Kan A, Jagannath C, Komatsu M, Eissa N Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity, 2013;39(3):537-47. 2013 [PMID: 24035364] (Flow Cytometry, Mouse) Flow Cytometry Mouse
The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis. Kidney Int, 2012;82(7):759-70. 2012 [PMID: 22622498] (Neutralization, Mouse) Neutralization Mouse
Qian J, Yi H, Guo C, Yu X, Zuo D, Chen X, Kane JM, Repasky EA, Subjeck JR, Wang XY CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma. J. Immunol., 2011;187(6):2905-14. 2011 [PMID: 21832164] (Western Blot, Mouse) Western Blot Mouse
Guimaraes EL, Empsen C, Geerts A, van Grunsven LA Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells. J. Hepatol., 2010;52(3):389-97. 2010 [PMID: 20133001] (Western Blot, Mouse) Western Blot Mouse
Yi H, Yu X, Gao P, Wang Y, Baek SH, Chen X, Kim HL, Subjeck JR, Wang XY Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation. Blood, 2009;113(23):5819-28. 2009 [PMID: 19349620] (Western Blot, Mouse) Western Blot Mouse
Okutsu R, Yoshikawa T, Nagasawa M, Hirose Y, Takase H, Mitani K, Okada K, Miyakoda G, Yabuuchi Y Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophages. Atherosclerosis, 2009;204(2):405-11. 2009 [PMID: 19108834] (Western Blot, Mouse) Western Blot Mouse

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Biotin BAF1797

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Bioinformatics

Gene Symbol MSR1
Uniprot