SPG3A Antibody - BSA Free

Analysis in human cerebral cortex and skeletal muscle tissues using Anti-ATL1 antibody. Corresponding ATL1 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234] - Staining of human cerebral cortex shows high expression.

Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234] - Staining of human skeletal muscle shows low expression as expected.

• Reactivity: Hu, Mu, Rt
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

SPG3A Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit SPG3A Antibody - BSA Free (NBP1-90234) is a polyclonal antibody validated for use in IHC. Anti-SPG3A Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: IPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQLESE
• Predicted Species: Rat (98%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ATL1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  SPG3A Protein (NBP1-90234PEP)

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 28726976).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for SPG3A Antibody - BSA Free

• AD-FSP
• ATL1
• atlastin GTPase 1
• atlastin1
• atlastin-1
• Brain-specific GTP-binding protein
• EC 3.6.5.-
• FSP1
• GBP3
• GBP-3
• GTP-binding protein 3
• Guanine nucleotide-binding protein 3
• guanylate-binding protein 3
• hGBP3
• Spastic paraplegia 3 protein A
• spastic paraplegia 3A (autosomal dominant)
• SPG3
• SPG3A
• SPG3AhGBP3

Background

SPG3A is encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SPG3A Antibody (NBP1-90234)(1)

Publication using NBP1-90234

• Schaefer K, Schutz E, Bochenek ML et al. Absence of transforming growth factor beta 1 in murine platelets reduces neointima formation without affecting arterial thrombosis Thromb. Haemost. 2017-07-20 [PMID: 28726976] (IHC-P, Mouse)

Bioinformatics

• Gene Symbol: ATL1