GBP1 Antibody

Images

 
Western Blot: GBP1 Antibody [NBP2-03972] - Analysis of GBP1 using GBP1 polyclonal antibody. Human HCT-116 lysate in the absence (1) and presence (2) of immunizing peptide and mouse RAW cell lysate (3) probed with GBP1 ...read more
Immunohistochemistry-Paraffin: GBP1 Antibody [NBP2-03972] - Analysis of GBP1 using GBP1 polyclonal antibody. Human rectum tissue probed with GBP1 antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

GBP1 Antibody Summary

Immunogen
A portion of amino acids 500-550 of human GBP1 was used as the immunogen for this antibody.
Predicted Species
Rat (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GBP1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2-4 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Reacts with Human and Mouse. The amino acid sequence used as immunogen has 100% identity in human, 95% in rat and 79% in mouse

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for GBP1 Antibody

  • GBP-1
  • GTP-binding protein 1
  • Guanine nucleotide-binding protein 1
  • guanylate binding protein 1, interferon-inducible
  • guanylate binding protein 1, interferon-inducible, 67kDa
  • huGBP-1
  • interferon-induced guanylate-binding protein 1

Background

GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules (Kunzelman, 2006). GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a (Naschberger, 2004). Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement (Naschberger, 2004). Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells (Guenzi, 2003). As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GBP1
Uniprot