SOX4 Antibody

Western Blot: SOX4 Antibody [NBP1-50776] - Analysis of SOX4 antibody in A2058 cell line lysates(35 ug/lane). SOX4 (arrow) was detected usingthe purified pAb.

Product Discontinued

SOX4 Antibody Summary

• Immunogen: Synthetic peptide selected from the N-terminal region of human SOX4
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SOX4
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 2.5 - 5 ug/mL

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 0.5% BSA, 50% Glycerol
• Preservative: 0.03% Proclin 300
• Concentration: 0.25 mg/ml
• Purity: Affinity purified

Alternate Names for SOX4 Antibody

• ecotropic viral integration site 16
• EVI16
• SRY (sex determining region Y)-box 4
• SRY-related HMG-box gene 4
• transcription factor SOX-4

Background

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SOX4 Antibody (NBP1-50776)(3)

Publications using NBP1-50776

• Kuo CY, Hsu YC, Liu CL et al. SOX4 is a pivotal regulator of tumorigenesis in differentiated thyroid cancer Molecular and cellular endocrinology 2023-09-04 [PMID: 37673293] (WB, Human)
• Liu H, Wu Z, Zhou H et al. The SOX4/miR-17-92/RB1 Axis Promotes Prostate Cancer Progression Neoplasia 2019-06-22 [PMID: 31238254] (WB, Human)
• Ruebel KH, Leontovich AA, Tanizaki Y et al. Effects of TGFbeta1 on gene expression in the HP75 human pituitary tumor cell line identified by gene expression profiling. Endocrine. 2008-02-01 [PMID: 18401765] (WB, Human)

Bioinformatics

• Gene Symbol: SOX4
• Entrez:
  • 6659(Human)
• Uniprot:
  • Q06945(Human)