SOX1 Antibody [Unconjugated]

Western blot shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for SOX1 at approximately 39 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

SOX1 was detected in immersion fixed BG01V human embryonic stem cells differentiated into neural progenitor cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Nestin was also detected using Mouse Anti-Mouse/Rat Nestin Monoclonal Antibody (Catalog # MAB2736) and stained using the NorthernLights™ 493-conjugated Anti-Mouse IgG Secondary Antibody (green; Catalog # NL009). Specific staining of SOX1 was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.

SOX1 was detected in immersion fixed NTera‑2 human testicular embryonic carcinoma cell line differentiated with retinoic acid using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green, upper panel; Catalog # NL003) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

SOX1 was detected in immersion fixed rat cortical stem cells (Catalog # NSC001) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; Catalog # NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

SOX1 was detected in immersion fixed mouse cortical stem cells (Catalog # NSC002) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; Catalog # NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

SOX1 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei in neuron. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Simple Western lane view shows lysates of undifferentiated iBJ6 human iPS cells andiBJ6 human iPS cells differentiated into neuroprogenitor cells, loaded at 0.2 mg/mL. A specific band was detected for SOX1 at approximately 50 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

• Reactivity: Hu, Mu, Rt
• Applications: WB, Simple Western, IHC, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

SOX1 Antibody [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant human SOX1
  Asn242-Gly379 (Leu276Ile)
  Accession # NP_005977
• Specificity: Detects human SOX1 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SOX1
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 3-15 ug/mL
  • Simple Western 10 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX1 Antibody [Unconjugated]

• SOX1
• SRY (sex determining region Y)-box 1
• SRY-related HMG-box gene 1
• transcription factor SOX-1

Background

SOX1 is a 39 kDa transcription factor that belongs to the SOXB1 subgroup. Within the developing CNS, SOX1 maintains neural cells in an undifferentiated state and has been used as a marker for neural stem cells. Human and mouse SOX1 share 97% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SOX1 Antibody (AF3369)(62)

Publications using AF3369

• Chang, SY;Wu, TH;Shih, YL;Chen, YC;Su, HY;Chian, CF;Lin, YW; SOX1 Functions as a Tumor Suppressor by Repressing HES1 in Lung Cancer Cancers 2023-04-08 [PMID: 37190139] (ICC, Western Blot, Human)
• J Sidhaye, P Trepte, N Sepke, M Novatchkov, M Schutzbier, G Dürnberger, K Mechtler, JA Knoblich Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids Elife, 2023-03-29;12(0):. 2023-03-29 [PMID: 36989136] (IHC, Mouse)
• JT Czerminski, OD King, JB Lawrence Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments Frontiers in Neuroscience, 2023-02-03;16(0):972201. 2023-02-03 [PMID: 36817096] (IHC, Human)
• J Sun, S Osenberg, A Irwin, LH Ma, N Lee, Y Xiang, F Li, YW Wan, IH Park, M Maletic-Sa, N Ballas Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation Cell Reports, 2023-01-05;42(1):111942. 2023-01-05 [PMID: 36640327] (IHC, Human)
• R Yelagandul, K Stecher, M Novatchkov, L Michetti, G Michlits, J Wang, P Hofbauer, G Vainorius, C Pribitzer, L Isbel, S Mendjan, D Schübeler, U Elling, J Brennecke, O Bell ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers Nature Cell Biology, 2023-01-05;0(0):. 2023-01-05 [PMID: 36604593] (ICC, Mouse)
• L Li, X Si, J Yang, M Lei, H Liu, J Ruan, H Fu, W Li, H Yang, X Lei, H Sang Generation of a human iPSC line (CIBi014-A) from a patient with Parkinson's disease carrying a novel heterozygotic PARK8 (LRRK2) mutation Stem Cell Research, 2022-12-09;66(0):102995. 2022-12-09 [PMID: 36528012] (ICC, Human)
• MV Brady, J Mariani, Y Koca, A Szekely, RA King, MH Bloch, A Landeros-W, JF Leckman, FM Vaccarino Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids Molecular Psychiatry, 2022-11-29;0(0):. 2022-11-29 [PMID: 36447010] (IHC, Human)
• H Lin, SQ Ye, ZH Xu, JS Penaloza, M Aljuhani, T Vetter, MT Zhao, KL McBride Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with congenital heart disease (CHD) Stem Cell Research, 2022-10-31;65(0):102958. 2022-10-31 [PMID: 36343514] (ICC, Human)
• Y Zheng, CM Gallegos, H Xue, S Li, DH Kim, H Zhou, X Xia, Y Liu, Q Cao Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Promotes Forelimb Functional Recovery after Cervical Spinal Cord Injury Cells, 2022-09-05;11(17):. 2022-09-05 [PMID: 36078173] (ICC, Human)
• M Rhinn, I Zapata-Bod, A Klein, JL Plassat, T Knauer-Mey, WM Keyes Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects PloS Biology, 2022-06-14;20(6):e3001664. 2022-06-14 [PMID: 35700169] (IHC, Human)
• P Mencke, I Boussaad, G Önal, AJA Kievit, AJW Boon, W Mandemaker, V Bonifati, R Krüger Generation and characterization of a genetic Parkinson's disease-patient derived iPSC line DJ-1-delP (LCSBi008-A) Stem Cell Research, 2022-04-26;62(0):102792. 2022-04-26 [PMID: 35500378] (ICC, Human)
• M Tisch, M Carmen De, M Suarez-Cub, C Fauth, M Defrancesc, J Zschocke, K Günther, F Edenhofer Generation of the human induced pluripotent stem cell line (IBKMOLi002-A) from PBMCs of a patient carrying the heterozygous L271H mutation of the voltage-gated calcium channel subunit Cav1.3-encoding CACNA1D gene Stem Cell Research, 2022-04-09;61(0):102784. 2022-04-09 [PMID: 35453044] (ICC, Human)
• X Zhu, Y Guo, C Chu, D Liu, K Duan, Y Yin, C Si, Y Kang, J Yao, X Du, J Li, S Zhao, Z Ai, Q Zhu, W Ji, Y Niu, T Li BRN2 as a key gene drives the early primate telencephalon development Science Advances, 2022-03-04;8(9):eabl7263. 2022-03-04 [PMID: 35245119] (IHC, Primate (Macaca fascicularis))
• KG Zyner, A Simeone, SM Flynn, C Doyle, G Marsico, S Adhikari, G Portella, D Tannahill, S Balasubram G-quadruplex DNA structures in human stem cells and differentiation Nature Communications, 2022-01-10;13(1):142. 2022-01-10 [PMID: 35013231] (ICC, Human)
• HS Meharena, A Marco, V Dileep, ER Lockshin, GY Akatsu, J Mullahoo, LA Watson, T Ko, LN Guerin, F Abdurrob, S Rengarajan, M Papanastas, JD Jaffe, LH Tsai Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors Cell Stem Cell, 2022-01-06;29(1):116-130.e7. 2022-01-06 [PMID: 34995493] (ICC, Human)
• T Pachano, V Sánchez-Ga, T Ealo, M Mariner-Fa, T Bleckwehl, HG Asenjo, P Respuela, S Cruz-Molin, M Muñoz-San, E Haro, WFJ van IJcken, D Landeira, A Rada-Igles Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness Nature Genetics, 2021-06-28;53(7):1036-1049. 2021-06-28 [PMID: 34183853] (IHC, Mouse)
• DM Dykxhoorn, X Tong, NC Gosstola, XZ Liu Derivation of iPSC line UMi029-A bearing a hearing-loss associated variant in the SMPX gene Stem Cell Research, 2021-05-24;54(0):102405. 2021-05-24 [PMID: 34052664] (ICC, Human)
• KP Kim, C Li, D Bunina, HW Jeong, J Ghelman, J Yoon, B Shin, H Park, DW Han, JB Zaugg, J Kim, T Kuhlmann, RH Adams, KM Noh, SA Goldman, HR Schöler Donor cell memory confers a metastable state of directly converted cells Cell Stem Cell, 2021-04-12;0(0):. 2021-04-12 [PMID: 33848472] (ICC, Mouse)
• V Krenn, C Bosone, TR Burkard, J Spanier, U Kalinke, A Calistri, C Salata, R Rilo Chris, P Pestana Ga, A Mirazimi, JA Knoblich Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly Cell Stem Cell, 2021-04-09;0(0):. 2021-04-09 [PMID: 33838105] (IHC, Human)
• C Gong, X Zheng, F Guo, Y Wang, S Zhang, J Chen, X Sun, SZA Shah, Y Zheng, X Li, Y Yin, Q Li, X Huang, T Guo, X Han, SC Zhang, W Wang, H Chen Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury Cell Reports, 2021-03-23;34(12):108889. 2021-03-23 [PMID: 33761348] (IHC, Rat)
• T Malankhano, L Suldina, E Grigor'eva, S Medvedev, J Minina, K Morozova, E Kiseleva, S Zakian, A Malakhova A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington's Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities J Pers Med, 2020-11-09;10(4):. 2020-11-09 [PMID: 33182269] (ICC, Human)
• A Lundin, MJ Porritt, H Jaiswal, F Seeliger, C Johansson, AW Bidar, L Badertsche, S Wimberger, EJ Davies, E Hardaker, CP Martins, E James, T Admyre, A Taheri-Gha, J Bradley, A Schantz, B Alaeimahab, M Clausen, X Xu, LM Mayr, R Nitsch, M Bohlooly-Y, ST Barry, M Maresca Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery Nat Commun, 2020-09-29;11(1):4903. 2020-09-29 [PMID: 32994412] (ICC, Human)
• JM Dias, Z Alekseenko, A Jeggari, M Boareto, J Vollmer, M Kozhevniko, H Wang, MP Matise, A Alexeyenko, D Iber, J Ericson A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells Science Advances, 2020-09-16;6(38):. 2020-09-16 [PMID: 32938678] (ICC, Mouse)
• K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates Sci Rep, 2020-08-20;10(1):14047. 2020-08-20 [PMID: 32820178] (ICC, Human)
• S Martins, A Müller-Sch, L Erichsen, M Bohndorf, W Wruck, K Sleegers, C Van Broeck, C Korth, J Adjaye IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an A&beta-Induced Gene Regulatory Network Int J Mol Sci, 2020-06-25;21(12):. 2020-06-25 [PMID: 32630447] (ICC, Human)
• V Meraviglia, CH Arendzen, M Tok, C Freund, AS Maione, E Sommariva, M Bellin Generation of human induced pluripotent stem cell line LUMCi027-A and its isogenic gene-corrected line from a patient affected by arrhythmogenic cardiomyopathy and carrying the c.2013delC PKP2 mutation Stem Cell Res, 2020-05-05;46(0):101835. 2020-05-05 [PMID: 32485643] (ICC, Human)
• V Meraviglia, CH Arendzen, C Freund, DE Atsma, CL Mummery, M Bellin Generation of two human induced pluripotent stem cell lines, LUMCi020-A and LUMCi021-A, from two patients with Catecholaminergic Polymorphic Ventricular Tachycardia carrying heterozygous mutations in the RYR2 gene Stem Cell Res, 2020-04-08;45(0):101764. 2020-04-08 [PMID: 32315959] (ICC, Human)
• N Bredenkamp, J Yang, J Clarke, GG Stirparo, F von Meyenn, S Dietmann, D Baker, R Drummond, Y Ren, D Li, C Wu, M Rostovskay, S Eminli-Mei, A Smith, G Guo Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency Stem Cell Reports, 2019-11-07;13(6):1083-1098. 2019-11-07 [PMID: 31708477] (ICC, Human)
• P Wörsdörfer, N Dalda, A Kern, S Krüger, N Wagner, CK Kwok, E Henke, S Ergün Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells Sci Rep, 2019-10-30;9(1):15663. 2019-10-30 [PMID: 31666641] (IHC-P, Human)
• B Di Stefano, EC Luo, C Haggerty, S Aigner, J Charlton, J Brumbaugh, F Ji, I Rabano Jim, KJ Clowers, AJ Huebner, K Clement, I Lipchina, MAC de Kort, A Anselmo, J Pulice, MFM Gerli, H Gu, SP Gygi, RI Sadreyev, A Meissner, GW Yeo, K Hochedling The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis Cell Stem Cell, 2019-10-03;0(0):. 2019-10-03 [PMID: 31588046] (ICC, Human)
• S Park, JE Yoo, DR Lee, J Jang, MS Cho, DS Kim, DW Kim Establishment of PITX3-mCherry knock-in reporter human embryonic stem cell line (WAe009-A-23) Stem Cell Res, 2019-07-18;39(0):101499. 2019-07-18 [PMID: 31352199] (ICC, Human)
• M Huang, J Tailor, Q Zhen, AH Gillmor, ML Miller, H Weishaupt, J Chen, T Zheng, EK Nash, LK McHenry, Z An, F Ye, Y Takashima, J Clarke, H Ayetey, FMG Cavalli, B Luu, BS Moriarity, S Ilkhanizad, L Chavez, C Yu, KM Kurian, T Magnaldo, N Sevenet, P Koch, SM Pollard, P Dirks, MP Snyder, DA Largaespad, YJ Cho, JJ Phillips, FJ Swartling, AS Morrissy, M Kool, SM Pfister, MD Taylor, A Smith, WA Weiss Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis Cell Stem Cell, 2019-06-13;0(0):. 2019-06-13 [PMID: 31204176] (IHC, Human)
• S Chanda, CE Ang, QY Lee, M Ghebrial, D Haag, Y Shibuya, M Wernig, TC Südhof Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity Cell Stem Cell, 2019-05-30;25(1):103-119.e6. 2019-05-30 [PMID: 31155484] (ICC, Human)
• J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family PLoS ONE, 2018-12-12;13(12):e0208110. 2018-12-12 [PMID: 30540809] (ICC, Human)
• Y Kang, Z Ai, K Duan, C Si, Y Wang, Y Zheng, J He, Y Yin, S Zhao, B Niu, X Zhu, L Liu, L Xiang, L Zhang, Y Niu, W Ji, T Li Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys Cell Rep, 2018-11-27;25(9):2563-2576.e9. 2018-11-27 [PMID: 30485820] (ICC, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells Nat Commun, 2018-09-13;9(1):3708. 2018-09-13 [PMID: 30213958] (ICC, Mouse)
• AD Senft, I Costello, HW King, AW Mould, EK Bikoff, EJ Robertson Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming Cell Rep, 2018-08-21;24(8):1977-1985.e7. 2018-08-21 [PMID: 30134160] (ICC, Human)
• CV Latchouman, L Jackson, MSE Sendi, KF Tehrani, LJ Mortensen, SL Stice, M Ghovanloo, L Karumbaiah Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro Sci Rep, 2018-07-19;8(1):10957. 2018-07-19 [PMID: 30026496] (ICC, Mouse)
• WA Pastor, W Liu, D Chen, J Ho, R Kim, TJ Hunt, A Lukianchik, X Liu, JM Polo, SE Jacobsen, AT Clark TFAP2C regulates transcription in human naive pluripotency by opening enhancers Nat. Cell Biol., 2018-04-25;20(5):553-564. 2018-04-25 [PMID: 29695788] (Western Blot, Human)
• JY Kim, JS Lee, HS Hwang, DR Lee, CY Park, SJ Jung, YR You, DS Kim, DW Kim Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells Exp. Mol. Med., 2018-04-13;50(4):24. 2018-04-13 [PMID: 29650976] (ICC, Human)
• NS Corsini, AM Peer, P Moeseneder, M Roiuk, TR Burkard, HC Theussl, I Moll, JA Knoblich Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation Cell Stem Cell, 2018-04-05;22(4):543-558.e12. 2018-04-05 [PMID: 29625069] (IHC, Mouse)
• M Zhang, J Ngo, F Pirozzi, YP Sun, A Wynshaw-Bo Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells Stem Cell Res Ther, 2018-03-15;9(1):67. 2018-03-15 [PMID: 29544541] (ICC, Human)
• L Marrone, C Bus, D Schöndorf, JC Fitzgerald, M Kübler, B Schmid, P Reinhardt, L Reinhardt, M Deleidi, T Levin, A Meixner, B Klink, M Glatza, CJ Gloeckner, T Gasser, J Sternecker Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease PLoS ONE, 2018-03-07;13(3):e0192497. 2018-03-07 [PMID: 29513666] (ICC, Human)
• P Walsh, V Truong, C Hill, ND Stoflet, J Baden, WC Low, SA Keirstead, JR Dutton, AM Parr Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells Cell Transplant, 2017-12-01;26(12):1890-1902. 2017-12-01 [PMID: 29390875] (ICC, Human)
• Y Li, R Wang, N Qiao, G Peng, K Zhang, K Tang, JJ Han, N Jing Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells J. Biol. Chem., 2017-09-26;292(48):19590-19604. 2017-09-26 [PMID: 28972157] (ICC, Human)
• X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model PLoS ONE, 2017-04-25;12(4):e0174074. 2017-04-25 [PMID: 28441409] (ICC, Human)
• ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes Am. J. Hum. Genet., 2017-03-30;100(4):617-634. 2017-03-30 [PMID: 28366443] (ICC, Human)
• T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells PLoS ONE, 2017-02-13;12(2):e0171947. 2017-02-13 [PMID: 28192470] (ICC, Human)
• L Subramania, M Bershteyn, MF Paredes, AR Kriegstein Dynamic behaviour of human neuroepithelial cells in the developing forebrain Nat Commun, 2017-01-31;8(0):14167. 2017-01-31 [PMID: 28139695] (IHC, Human)
• M Bershteyn, TJ Nowakowski, AA Pollen, E Di Lullo, A Nene, A Wynshaw-Bo, AR Kriegstein Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia Cell Stem Cell, 2017-01-19;0(0):. 2017-01-19 [PMID: 28111201] (ICC, Human)
• Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and�Motility Stem Cell Reports, 2016-12-29;0(0):. 2016-12-29 [PMID: 28041877] (IHC, Mouse)
• Rui Gao Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state Biomaterials, 2016-12-10;119(0):53-67. 2016-12-10 [PMID: 28006658] (IHC, Mouse)
• Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A Stem Cells Transl Med, 2016-08-02;0(0):. 2016-08-02 [PMID: 27484861] (IHC-Fr, Human)
• Nagaoka M, Kobayashi M, Kawai C, Mallanna S, Duncan S Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells. PLoS ONE, 2015-08-26;10(8):e0136350. 2015-08-26 [PMID: 26308339] (IHC, Human)
• Paull D, Sevilla A, Zhou H, Hahn A, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard C, Sun B, Vilboux T, Zimmer M, Forero E, Moroziewicz D, Martinez H, Malicdan M, Weiss K, Vensand L, Dusenberry C, Polus H, Sy K, Kahler D, Gahl W, Solomon S, Chang S, Meissner A, Eggan K, Noggle S Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nat Methods, 2015-08-03;12(9):885-92. 2015-08-03 [PMID: 26237226] (IHC, Mouse)
• Villa-Diaz L, Kim J, Lahann J, Krebsbach P Derivation and long-term culture of transgene-free human induced pluripotent stem cells on synthetic substrates. Stem Cells Transl Med, 2014-10-13;3(12):1410-7. 2014-10-13 [PMID: 25313201] (ICC, Human)
• Simone C, Nizzardo M, Rizzo F, Ruggieri M, Riboldi G, Salani S, Bucchia M, Bresolin N, Comi G, Corti S iPSC-Derived neural stem cells act via kinase inhibition to exert neuroprotective effects in spinal muscular atrophy with respiratory distress type 1. Stem Cell Reports, 2014-07-04;3(2):297-311. 2014-07-04 [PMID: 25254343] (IHC, Human)
• Ferrarese R, Harsh G, Yadav A, Bug E, Maticzka D, Reichardt W, Dombrowski S, Miller T, Masilamani A, Dai F, Kim H, Hadler M, Scholtens D, Yu I, Beck J, Srinivasasainagendra V, Costa F, Baxan N, Pfeifer D, von Elverfeldt D, Backofen R, Weyerbrock A, Duarte C, He X, Prinz M, Chandler J, Vogel H, Chakravarti A, Rich J, Carro M, Bredel M Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. J Clin Invest, 2014-05-27;124(7):2861-76. 2014-05-27 [PMID: 24865424] (ICC, Human)
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Bioinformatics

• Gene Symbol: SOX1
• Uniprot:
  • NP_005977()