Smoothened Antibody (1015418) [Allophycocyanin]

• Reactivity: Hu
• Applications: IHC
• Clone: 1015418
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

Smoothened Antibody (1015418) [Allophycocyanin] Summary

• Immunogen: Chinese Hamster Ovary cell line, CHO-derived human Smoothened
  Met1-Tyr233
  Accession # Q99835
• Specificity: Detects human Smoothened in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for Smoothened Antibody (1015418) [Allophycocyanin]

• bnb
• CRJS
• FZD11
• Gx
• Protein Gx
• SMO
• SMOH
• SMOHseven transmembrane helix receptor
• smoothened (Drosophila) homolog
• smoothened homolog (Drosophila)
• smoothened homolog
• Smoothened

Background

Smoothened, a Frizzled Receptor, is homologous to the Drosophila segment polarity Smo gene. It associates with the Patched protein to mediate the cellular response to the Hedgehog secreted protein signal, which controls patterning and growth during vertebrate development. Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas. Smoothened expression has been documented in bladder, blood, brain, the central nervous system, skin, and ureter. ESTs have been isolated from amnion, bone, brain, breast, embryo, eye, heart, nerve, and skin libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.