Pancreatic Cancer Research Targets Hedgehog Signaling Pathway

Thu, 08/18/2011 - 14:08

The Hedgehog Signaling Pathway (HSP) is an important pathway involved in embryonic development by regulating cell differentiation. This pathway has also become an increasingly hot topic in cancer research in recent years. The HSP involves the interaction between several targets to activate members of the Gli family of transcription factors, such as Gli1, Gli2, and Gli3.
The HSP is activated when Hegehog homolog (Sonic Hedgehog, Desert Hedgehog, Indian Hedgehog) binds to Patched (PTCH). This binding to PTCH by the Hedgehog homolog induces activation of Smoothened (Smo). This causes a buildup of Ci protein in the cytoplasm. The Ci protein translocates to the nucleus and activates the Gli family.

Immunohistochemistry-Paraffin: Sonic Hedgehog Antibody

Walter, et al [PMID: 20215540] aimed to show that signaling pathways, such as the HSP, are involved in tumor-stromal cell interactions in pancreatic cancer in humans. Through research conducted by Walter et al, they were able to show that overexpression of Smo occurs in human pancreatic adenocarcinomas via immunohistochemistry. This research proves promising in that targeting Smo can be a potential treatment for pancreatic cancer down the road.

Novus Biologicals currently offers several antibodies against targets in the Hedgehog pathway.

Please feel free to use our Novus Explorer tool to research additional publications related to research on the Hedgehog Signaling Pathway. This tool allows you to see related genes, pathways, or diseases and links to publications found referencing both.


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