Smoothened Antibody (1015418) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: IHC
• Clone: 1015418
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Smoothened Antibody (1015418) [Alexa Fluor® 700] Summary

• Immunogen: Chinese Hamster Ovary cell line, CHO-derived human Smoothened
  Met1-Tyr233
  Accession # Q99835
• Specificity: Detects human Smoothened in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Smoothened Antibody (1015418) [Alexa Fluor® 700]

• bnb
• CRJS
• FZD11
• Gx
• Protein Gx
• SMO
• SMOH
• SMOHseven transmembrane helix receptor
• smoothened (Drosophila) homolog
• smoothened homolog (Drosophila)
• smoothened homolog
• Smoothened

Background

Smoothened homolog (SMO) is a G protein-coupled receptor that is a component of the hedgehog signaling pathway. SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and serve as driving mutations for cancers such as medulloblastoma, basal-cell carcinoma, pancreatic cancer, and prostate cancer. As such, SMO is an attractive cancer drug target, along with the many hedgehog pathway agonists and antagonists that are known to directly target SMO.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.