Smoothelin Antibody (885424) [Unconjugated] - B

Images

 
Smoothelin B was detected in formalin fixed paraffin-embedded sections of human colon using Mouse Anti-Human Smoothelin B Monoclonal Antibody (Catalog # MAB8278) at 5 µg/mL overnight at 4 °C. Tissue was stained using ...read more
HASMC human aortic smooth muscle cells was stained with Mouse Anti-Human Smoothelin B Monoclonal Antibody (Catalog # MAB8278, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, CyTOF-ready, Flow
Clone
885424
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Smoothelin Antibody (885424) [Unconjugated] - B Summary

Immunogen
E. coli-derived recombinant human Smoothelin B
Met1-Leu132
Accession # P53814
Specificity
Detects human Smoothelin B in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SMTN
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-25 ug/mL
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Smoothelin Antibody (885424) [Unconjugated] - B

  • FLJ35365
  • FLJ38597
  • Smoothelin
  • SMSMO
  • SMTN

Background

Smoothelin (SMTN) is a cytoskeletal protein associated with stress fibers.  It is 917 amino acids (aa) in length and shares 77% and 82% aa identity with mouse and rat SMTN.  SMTN has two major isoforms, A and B with reported molecular weights of approximately 59 and 110 kDa, respectively.  Isoform A is associated with visceral smooth muscle cells while isoform B is specific to vascular smooth muscle.  Loss of SMTN has been associated with defects in intestinal smooth muscle cell contraction as well as increased arterial pressure and cardiac hypertrophy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Smoothelin Antibody (MAB8278) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SMTN
Uniprot
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