Smoothelin Antibody (885424) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 885424
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

Smoothelin Antibody (885424) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human Smoothelin B in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Smoothelin Antibody (885424) [Alexa Fluor™ Plus 488]

• FLJ35365
• FLJ38597
• Smoothelin
• SMSMO
• SMTN

Background

Smoothelin (SMTN) is a cytoskeletal protein associated with stress fibers.  It is 917 amino acids (aa) in length and shares 77% and 82% aa identity with mouse and rat SMTN.  SMTN has two major isoforms, A and B with reported molecular weights of approximately 59 and 110 kDa, respectively.  Isoform A is associated with visceral smooth muscle cells while isoform B is specific to vascular smooth muscle.  Loss of SMTN has been associated with defects in intestinal smooth muscle cell contraction as well as increased arterial pressure and cardiac hypertrophy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.