SLURP1 Antibody

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SLURP1 was detected in immersion fixed paraffin-embedded sections of human skin using Sheep Anti-Human SLURP1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4479) at 15 µg/mL overnight at 4 °C. Tissue was ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

SLURP1 Antibody Summary

Immunogen
E. coli-derived recombinant human SLURP1
Ala22-Leu103
Accession # P55000
Specificity
Detects human SLURP1 in direct ELISAs. In direct ELISAs, less than 3% cross-reactivity with recombinant mouse SLURP1 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
SLURP1
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-15 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Sterile PBS to a final concentration of 0.2 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SLURP1 Antibody

  • ANUPARS(component B)-81/S
  • ARS Component B
  • ArsB
  • ARSlymphocyte antigen 6-like secreted
  • LY6LS
  • MDMsecreted Ly-6/uPAR-related protein 1
  • neoplastic urinary protein
  • secreted LY6/PLAUR domain containing 1
  • secreted Ly6/uPAR related protein 1
  • SLURP1
  • SLURP-1

Background

SLURP1 (Secreted Ly6/uPAR-related protein 1; also ARS Component B and ANUP) is a 9-10 kDa secreted member of the Ly6/uPAR Superfamily of proteins. It is expressed by restricted cell types, including sensory neurons, ciliated bronchial epithelium, T and B cells, and stratified squamous epithelium of the skin, vagina and esophagus. SLURP1 binds to the alpha 7 nicotinic acetylcholine receptor, which suggests it regulates Ca and Na transport. This translates into reduced TNF alpha release by macrophages, and activation of select cellular caspases. Mature human SLURP1 is 82 amino acids (aa) in length (aa 22-103). It contains one UPAR/Ly6 domain (aa 24‑73), and forms noncovalent homodimers. Mature human SLURP1 shares 67% aa identity with mouse SLURP1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SLURP1
Uniprot