SLURP1 Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 750

SLURP1 Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human SLURP1
  Ala22-Leu103
  Accession # P55000
• Specificity: Detects human SLURP1 in direct ELISAs. In direct ELISAs, less than 3% cross-reactivity with recombinant mouse SLURP1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SLURP1 Antibody [Alexa Fluor® 750]

• ANUPARS(component B)-81/S
• ARS Component B
• ArsB
• ARSlymphocyte antigen 6-like secreted
• LY6LS
• MDMsecreted Ly-6/uPAR-related protein 1
• neoplastic urinary protein
• secreted LY6/PLAUR domain containing 1
• secreted Ly6/uPAR related protein 1
• SLURP1
• SLURP-1

Background

SLURP1 (Secreted Ly6/uPAR-related protein 1; also ARS Component B and ANUP) is a 9-10 kDa secreted member of the Ly6/uPAR Superfamily of proteins. It is expressed by restricted cell types, including sensory neurons, ciliated bronchial epithelium, T and B cells, and stratified squamous epithelium of the skin, vagina and esophagus. SLURP1 binds to the alpha 7 nicotinic acetylcholine receptor, which suggests it regulates Ca and Na transport. This translates into reduced TNF alpha release by macrophages, and activation of select cellular caspases. Mature human SLURP1 is 82 amino acids (aa) in length (aa 22-103). It contains one UPAR/Ly6 domain (aa 24‑73), and forms noncovalent homodimers. Mature human SLURP1 shares 67% aa identity with mouse SLURP1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.